Mitochondrial defense against an intracellular parasite (B09*)

线粒体调节无数的细胞功能，但在感染的背景下，这些动态的细胞器被认为是微生物可利用的目标。然而，事实上，病原体已经开发出扰乱线粒体功能的策略，支持线粒体对抗病原体的存在。我们的首要目标是加深我们对线粒体如何调节细胞防御微生物的理解。在这个项目中，我们将探索两种新的机制，线粒体防御感染人类寄生虫弓形虫。

Mitochondria regulate a myriad of cellular functions, but in the context of infection these dynamic organelles are considered exploitable targets for microbes. However, the fact that pathogens have developed strategies to perturb mitochondrial function supports the existence of mitochondrial counterstrategies to defend against pathogens. Our overarching goal is to deepen our understanding of how mitochondria regulate cellular defense against microbes. In this project, we will explore two novel mechanisms of mitochondrial defense during infection with human parasite Toxoplasma.