Development of Cancer Treatment System by Induction heating

本课题的基本要素有：1)感应加热装置2)磁流体适用于癌症患者3)磁流体治疗癌症方案我们对以上要素进行了研究。感应加热装置的研制1-1深部肿瘤应用器的研制涡流是人体所面临的严峻问题。因为它可能会导致烧伤。因此，我们采用三维人体模型对其进行了模拟。1.2高性能器件的开发利用“利兹线”改善了施药器线圈的铜损耗，利用铁氧体提高了电磁波的有效性。我们开发了一种新的共振控制系统技术，使设备的功率效率提高了2倍之多。高效磁流体的开发AIRI造影剂“Resovist”的更多成分可以通过离心分离、超滤、磁分离等多种方法分离成七种不同的组分。我们尝试了这种分离方法，获得了高效的磁流体分馏（HEMF）。特别是磁选是获得IMF的有效途径。HEMF的产热效率是原磁流体的5.7倍。为了明确HEMF与原始磁流体的区别，我们在电子显微镜下观察了成分纳米颗粒的形状。原始磁流体的粒径约为6nm。另一方面，HEMF成分的粒径大于20 μ m，由直径为5 ~ 6nm的小颗粒粉尘组成。如上所述，我们获得了高效的设备。效果比原装置提高10倍以上。我们制作了两台设备，并借给金泽大学医学院、福井大学富山大学、大阪老年病中心和实践动物医院等。这些装置被应用于各种实验性癌症，以制定有用的方案。实验结果表明，该装置对实验性肺癌、乳腺癌、杠杆癌等肿瘤有较好的治疗效果，具有较好的可行性。少

Essential elements of this project are as follows:1) Induction heating device2) Magnetic fluid t o be applicable for cancer patient3) Protocol for cancer treatment using magnetic fluidWe have researched about above mentioned elements.1. Development of induction heating device1-1 Development of applicator for deep seated cancerEddy current is a severe problem in case of human body. Because it might cause the burn. Therefore we have simulated it using the three dimension human body model.We have been able to realize the appropriate frequency and the suitable applicator type for deep seated cancer.1.2 Development of high performance deviceWe have improved the copper loss of applicator coil using "litz wire" and have improved the effectiveness of the electromagnetic wave using a ferrite. And we developed a new technology for resonance control system The power efficiency of the device increased to be as much as 2 times.2. Development of highly effective magnetic fluidMagnetic fluid, active … More ingredient of AIRI contrast agent "Resovist" is able to separate into seine fractions by various methods such as centrifugal separation, ultra-filtration, magnetic separation etc,. We have tried such separation and obtained highly effective magnetic fluid fraction(HEMF). Especially magnetic separation is effective to obtain IMF. Heat generation efficacy of the HEMF is 5.7 times in comparison with original magnetic fluid. In order to clarify the difference between the HEMF and original magnetic fluid, we have observed the shape of the ingredients nano-particles, under electron microscope. The particle size of original magnetic fluid is about 6nm. On the other hand the partide size of the ingredient of HEMF is more than 20 am that comprises with duster of small par-tides in diameter of 5〜6nm.3. Development of protocolAs mentioned above, we have obtained high efficient device. The effectiveness increased more than 10 times in comparison of former device. We made two devices and loaned to Faculty of Medicine Kanazawa University Fukui University Toyama University, the Osaka geriatric diseases center and the practicing animal hospital, etc. These devises were applied to various experimental cancer to develop useful protocols.We demonstrated induction heating hyperthermia using the device was effective for experimental lung cancer, breast cancer, lever cancer etc with favorable feasibility In summary we consider that this treatment system is a very beneficial and promising to cancer. Less