Chemical biology targeting the brain : Molecular design of anticancer agents that efficiently attack brain tumors

癌症化疗对脑肿瘤的疗效在很大程度上受到细胞机制的限制，其中血膜屏障限制了药物对大脑的渗透。三磷酸腺苷结合盒(ABC)转运蛋白，如ABCB1和ABCG2，发挥着关键作用。在这个研究项目中，我们开发了快速筛选和定量结构-活性-关系(QSAR)分析方法来设计有效靶向脑肿瘤的抗癌药物分子。

The efficacy of cancer chemotherapy in brain tumors is substantially limited by cellular mechanisms where the blood-bran-barrier limits drug penetration into the brain. ATP-binding cassette (ABC) transporters, e.g., ABCB1 and ABCG2, play pivotal roles. In this research project, we have developed high-speed screening and quantitative structure-activity-relationship (QSAR) analysis methods to design anticancer drug molecules that efficiently target brain tumors.