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Study on the structure and funciotion of supramolecular flagellar motor

Study on the structure and funciotion of supramolecular flagellar motor
超分子鞭毛马达的结构与功能研究
批准号:
18207011
负责人:
HOMMA Michio
金额:
$31.45万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2009

项目摘要

项目成果

HOMMA Michio的其他基金

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相关文献

中文摘要
翻译
其中,PomA、PomB、mox和MotY蛋白已被确定为鞭毛旋转所必需的运动蛋白。我们新发现的T环是装配所必需的。T环的组成蛋白MotY的结构以2.9 Å的分辨率确定。我们提出了鞭毛马达蛋白作为功能马达组装的分子动力学模型。结果表明,C环结构很容易与鞭毛基体分离。此外,我们发现FlgT是构建LP环外环的基础体成分。这个环被命名为H环。新的环可能有助于振动电机功能作为一个强大的轴,以支持电机的高速旋转。
英文摘要
The proteins, PomA, PomB, MotX and MotY have been identified as the motor proteins that are necessary for the flagella rotation. The T ring newly found by us is necessary for the assembly. The structure of the component protein, MotY, of the T ring is determined with a 2.9 Å resolution. We proposed the molecule dynamic model of the flagella motor proteins to assemble as a functional motor. We showed that the C ring structure was easily dissociated from the flagella base body. Furthermore we found that FlgT was the basal body component to construct a ring outside of the LP ring. The ring was named an H ring. The new ring may contribute on the Vibro motor function as a strong shaft to support the high-speed rotation of the motor.
期刊论文(48)
专著(0)
科研奖励(0)
会议论文
Cell-free synthesis of the torque-generating membrane proteins, PomA and PomB, of the Nat-driven flagellar motor in Vibrio alginolyticus.
溶藻弧菌 Nat 驱动的鞭毛马达的扭矩产生膜蛋白 PomA 和 PomB 的无细胞合成。
DOI: --
发表时间: 2008
期刊: J. Biochem. 144(5)
影响因子: --
作者: [Terashima, H., Abe-Yoshizumi, R., Kojima, S., Homma, M.]
通讯作者: M.
In vivo架橋を用いた大腸菌走化性における受容体クラスターの構造機能連関の解析
利用体内交联分析大肠杆菌趋化性受体簇的结构-功能关系
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [M. Isobe, M. Kurono, K. Tsuboi< and A. Takai, 入枝泰樹]
通讯作者: 入枝泰樹
Cell-free synthesis of the torque-generating membrane proteins
扭矩产生膜蛋白的无细胞合成
DOI: --
发表时间:
期刊: PomA and PomB, of the Na^+-driven flagellar motor in Vibrio alginolyticus. J Biochem 144
影响因子: --
作者: [Terashima H, Abe-Yoshizumi R, Kojima S, Homma M.]
通讯作者: Homma M.
Roles of charged residues of rotor and stator in flagellar rotation : Comparative study using H^+-driven and N^+-driven motors in Escherichia coli.
转子和定子带电残基在鞭毛旋转中的作用:在大肠杆菌中使用 H^ 驱动和 N^ 驱动电机的比较研究。
DOI: --
发表时间: 2006
期刊: J. Bacteriol. 188
影响因子: --
作者: [Yakushi, T., Yang, J.-H., Fukuoka, H., Homma, M., Blair D.]
通讯作者: Blair D.
共 20 条
    Analysis of the structural dynamics of the flagellar motor proteins using NMR
    • 批准号:
      24657099
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.58万
    • 财政年份:
      2012
    • 负责人:
      HOMMA Michio
    • 依托单位:
    Study on the dynamic structure change of membrane supramolecular flagellar motor and the force generation
    • 批准号:
      23247024
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $30.87万
    • 财政年份:
      2011
    • 负责人:
      HOMMA Michio
    • 依托单位:
    Roles of the chemotaxis and the motility by flagella on environmental response of Vibio cells
    • 批准号:
      16017241
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $9.41万
    • 财政年份:
      2004
    • 负责人:
      HOMMA Michio
    • 依托单位:
    Study on structure and function of force-generating proteins in ion-driven flagellar motor
    • 批准号:
      13308038
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $33.7万
    • 财政年份:
      2001
    • 负责人:
      HOMMA Michio
    • 依托单位:
    海外基金