Improvement of meat production by central regulation using a factor extracted from Shochu distillery by-product in fowls especially in native fowl

目前的研究表明，从Shochu酒厂副产物中发现的生长促进剂丁氧丁醇(BBA)可以降低肌肉蛋白质的降解。BBA的这种作用是由于降低了与骨骼肌蛋白分解相关的因子如钙蛋白酶、泛素和蛋白酶的基因表达。此外，本研究还表明，BBA导致生长激素(GH)、促肾上腺皮质激素(ACTH)和促肾上腺皮质激素释放激素(CRH)的分泌发生变化。BBA促进GH分泌，减少ACTH和CRH分泌。BBA增加了饲料摄入量，因为CRH减少，随后下丘脑中神经肽的合成。

The present study showed that the growth promoter buthoxybuthyl alcohol (BBA) found from Shochu distillery by-product reduces muscle proteolysis. This effect of BBA was caused by decreases in genes expressions of factors relating to the skeletal muscle proteolysis such as calpain, ubiquitin, and proteasome.Furthermore, the present study showed changes in secretions of growth hormone (GH), adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) due to BBA. BBA increased GH secretion and decreased secretions of ACTH and CRH. BBA increased feed intake because CRH is reduced followed by nerve peptides synthesis in the hypothalamus.