Targeted design of superalloy membranes and their application processes for the production of colloidal, lipid-based drug carrier systems

高温合金膜具有良好的机械强度和耐热性，具有纳米级的细孔。这些特性的结合是典型的膜材料如氧化铝、玻璃或聚合物所不能达到的。在制药纳米乳化工艺领域，预混膜乳化目前正在研究中，其中使用具有更高机械强度和耐热性的膜可以扩大过程控制的可能性，从而开辟新的应用可能性。在首次由申请机构联合进行的跨学科研究中，表明蠕变纳米多孔高温合金膜通常非常适合于预混膜乳化。申请中描述的项目，一方面是为了从根本上调查和探索预混膜乳化应用中膜制造的材料具体方面和挑战。并对高温合金膜的预混膜乳化工艺进行了详细的研究。这包括膜和药物乳剂之间的相互作用，探索可能的过程窗口和膜的程序表征。本研究的目的是全面了解纳米多孔高温合金膜作为替代膜材料的设计，并借助合适的模型试验台探索其工艺应用。高温合金膜领域的专业知识由材料研究所代表，而在工艺工程和制药领域，则由粒子技术研究所和制药技术研究所贡献。

Superalloy membranes combine good mechanical strength and thermal resistance with very fine pores in the nanometer range. The combination of these properties is not achieved by typical membrane materials such as alumina, glass or polymers. In the field of pharmaceutical nanoemulsification processes, premix membrane emulsification is currently being investigated amongst others, in which the use of membranes with increased mechanical strength and thermal resistance can expand the possibilities of process control and thus open up new application possibilities. In a first joint interdisciplinary study by the applicant institutes, it was shown that creep-deformed nanoporous superalloy membranes are generally well suited for premix membrane emulsification. The project described in the application is intended, on the one hand, to fundamentally investigate and explore the material specific aspects and challenges of membrane fabrication with regard to the application of premix membrane emulsification. Furthermore, the process of premix membrane emulsification with the superalloy membranes shall be investigated in detail. This includes the interactions between the membranes and the pharmaceutical emulsions, the exploration of possible process windows and the procedural characterization of the membranes. The aim of the research is to comprehensively understand the design of the nanoporous superalloy membranes as alternative membrane material and to explore their process application with the help of a suitable model test bench. While the expertise in the field of superalloy membranes is represented at the Institute of Materials, in the fields of process engineering and pharmacy it is contributed by the Institutes of Particle Technology and Pharmaceutical Technology.