Molecular dissection of salicylic acid signaling in systemic acquired resistance

NPR 1蛋白是水杨酸（SA）信号转导的关键转录辅激活因子。虽然NPR 1寡聚体的形成是其激活的先决条件，但其分子机制尚未完全阐明。在这里，我们已经确定EF-Tu作为植物NPR 1复合体的成员。我们发现EF-Tu参与了NPR 1寡聚体的稳定，以及对假单胞菌的抗病性。这强烈表明EF-Tu是SA介导的信号传导的正调节剂。

NPR1 protein is the key transcription coactivator in salicylic acid (SA) signaling. Although the formation of NPR1 oligomer is prerequisite for its activation, the molecular mechanism is not fully elucidated. Here we have identified EF-Tu as a member of NPR1 complex in planta. We found that EF-Tu is involved in the stabilization of NPR1 oligomer, and disease resistance against Pseudomonas syringae. It is strongly suggested that EF-Tu is a positive regulator of SA-mediated signaling.