The molecular biological analysis of the mechanism for cell adhesion mediated by growth factor in human gingival epithelial cells

牙周病是由牙周病原体感染引起的慢性炎症性疾病。据认为，大约80%的日本人受到影响，这是牙齿脱落的主要原因。目前尚不清楚每位患者牙周病进展的差异。认为牙龈上皮细胞与牙齿之间的附着是防止感染的物理屏障，这种附着对预防牙周病很重要。本研究假设牙龈上皮细胞分泌的生长因子调节牙龈上皮细胞与牙齿的附着，并探讨其作用机制。

Periodontal disease, chronic inflammation disease, is caused by infection of periodontal pathogen. It is thought that about 80% of Japanese are affected and it is a major cause of tooth loss. It is still unknown that the difference of progression of periodontal disease for each patient. It is thought that the attachment between gingival epithelial cells and tooth is a physical barrier from infection, and this attachment is important for prevention of periodontal disease. In this study, we hypothesis that growth factors secretes from gingival epithelial cells regulate the attachment between gingival epithelial cells and tooth, and we investigate the mechanism about the regulation.