Spray drying system for non-aqueous feeds

由于对制药产品研究兴趣的变化，需要一种新的喷雾塔来处理有机液体，并在封闭系统中使用氮气作为干燥气体。为了提高活性药物成分的溶出度，应设计新的分散系统，以生产亚微米颗粒(0.1-1微米)。此外，应该开发和测试新的制剂概念，如无定形固体分散体，将低溶解性药物嵌入亲水性聚合物中。这些技术应该被用来克服新药分子生物利用度低的问题，这被认为是当今药物开发的主要限制。

Due to a change in research interest towards pharmaceutical products, a new spray tower is required capable to handle organic liquids as well as using nitrogen as drying gas in a closed system. Submicron particles (0.1-1µm) should be produced designing new dispersing systems in order to increase the dissolution rate of active pharmaceutical ingredients. Furthermore, new formulation concepts like amorphous solid dispersions should be developed and tested where the low soluble drug is imbedded in hydrophilic polymer. These technologies should be used to overcome the low bioavailability of new drug molecules that is considered the main limitation in pharmaceutical development of these days.