Establishment of an early osteoporosis detection method using alveolar bone biopsy

在种植准备过程中提取牙槽骨活检样本，以调查绝经后微结构的变化，以及这些变化与骨转换标志物之间的关系。受试者为18例接受下颌种植的妇女：绝经前5例，绝经后早期3例，绝经后晚期10例。用微型计算机断层扫描和三维骨形态计量学对标本进行分析。绝经后晚期妇女牙槽骨体积明显小于绝经前妇女。绝经后早期妇女的骨小梁较绝经前妇女的骨小梁更分散，呈杆状。每个牙槽骨参数与至少一个骨转换标志物显著相关。牙槽松质骨结构甚至在绝经后早期就开始改变，这种结构的变化与骨转换标志物密切相关。

Alveolar bone biopsy samples were extracted during implant preparation, for investigating microstructural changes due to menopause, and relationships between these changes and bone turnover markers. Subjects were 18 women receiving mandibular implants: premenopausal (n = 5), early postmenopausal (n = 3), and late postmenopausal (n = 10). The samples analyzed using micro-computed tomography and three-dimensional bone morphometry. The alveolar bone volume was significantly less in late postmenopausal women than in premenopausal ones. The trabeculae in early postmenopausal women were more separated and rod-like than in premenopausal ones. Each alveolar bone parameter was significantly related to at least one bone turnover marker. Alveolar cancellous bone structure begins changing even in early postmenopausal women, and this structure varies in close relationship to bone turnover markers.