Sex-specific differences in immunity and infection: an integrative approach

越来越多的证据表明，对挑战的免疫反应强烈地受到个体性别的影响。我们假设，神经退行性疾病的发病、流行和进展中可观察到的性别偏见可能是由大脑免疫细胞的性别差异引起或加剧的。在这个项目中，我们将研究健康大脑中的性别特异性免疫衰老，并得出神经退行性变中观察到的性别偏见的潜在含义(目标1)。该项目的另一个基本假设是，将不同数据类型和疾病的免疫学中的性别差异整合在一起，应该会对特定性别的病理生理学产生新的见解。这是我们的第二个目标(目标2和3)，我们将建立一个语义集成平台，用于交互查询、可视化和分析跨器官、疾病、模式生物和治疗的性别特定免疫差异。该平台将使RU5068和全球研究界的研究人员能够根据公平原则轻松地获取和分析数据。随后对这些数据的综合分析将产生对免疫系统常见的和不同的中心性特定调节机制的基本见解，提供对可操作的分子、途径和细胞类型的见解(目标4)。

A growing amount of evidence suggests that immune reaction to challenge is strongly influenced by the sex of the individual. We hypothesize that the observable sex bias in neurodegenerative disease onset, prevalence, and progression might be caused or exacerbated by sex-specific differences of brain immune cells. In this project, we will investigate sex-specific immunosenescence in the healthy brain and derive potential implications for the observed sex biases in neurodegeneration (objective 1). Another fundamental assumption of this project is that the integration of sex differences in immunology across data types and diseases should yield novel insights into sex-specific pathophysiology. It is our second aim (objectives 2 & 3) we will build a semantic integration platform for the interactive querying, visualization, and analysis of sex-specific immune differences across organs, disease, model organism, and treatment. This platform will enable researchers of the RU 5068 and the global research community to easily access and analyse data according to FAIR principles. The subsequent integrative analysis of this data will yield fundamental insights into common and distinct central sex-specific regulatory mechanisms of the immune system, providing insights into actionable molecules, pathways, and cell types (objective 4).