Importance of UGT1A1 in breast milk-induced neonatal hyperbilirubinemia

udp -葡萄糖醛酸糖基转移酶（UGT） 1A1是唯一能代谢胆红素的酶。在本研究中，我们证明了UGT1A1不仅在肝脏和小肠中表达，而且在皮肤中表达。进一步证明，人母乳中所含的脂肪酸油酸、亚油酸和二十二碳六烯酸（DHA）对UGT1A1的活性有较强的抑制作用。

UDP-Glucuronosyltransferase (UGT) 1A1 is the sole enzyme that can metabolize bilirubin. In the present study, we demonstrated that UGT1A1 is expressed not only in the liver and small intestine, but also in the skin. It was further demonstrated that oleic acid, linoleic acid, and docosahexaenoic acid (DHA), which are fatty acids included in the human breast milk, can strongly inhibit the UGT1A1 activity.