Superconducting FT-NMR-Spectrometer 700 MHz

高分辨核磁共振波谱是现代化学分析中最重要的仪器之一。Justus Liebig大学目前迫切需要在这一领域采取行动，以获得一台配备N2冷却探头的现代700 MHz核磁共振波谱仪，以提高目前在测量少量合成和天然产物分离时以及在测量具有少量物质的较不敏感的异核时检测灵敏度不足的情况。有机化学研究所的NMR部门是大学内唯一的部门，因此负责所有测量，包括相关领域的测量。获得高性能NMR分析对许多工作组至关重要，NMR光谱学对他们至关重要。目前，我们最大的NMR光谱仪（600 MHz）的灵敏度和分辨率仅足以对最少量的物质和难溶性化合物进行结构解析。特别是，我们最大的NMR光谱仪的探头配置，一个5毫米的宽带探头自动调谐（ATM，13岁，经常需要维修）和5毫米的三重共振反向探头没有自动调谐是太不敏感的调查和分析少量的天然产物分离物。此外，溶剂的抑制和测量时间的延长对于非常少量的完整结构分析来说不够有效。具有N2冷却探头的700 MHz NMR光谱仪由于其更高的分辨率和灵敏度，可以研究最少量的物质和难溶性化合物，这些物质和难溶性化合物只能用现有设备进行不充分的处理。所要求的设备对于维持和扩大我们在NMR结构分析领域的能力也至关重要，也超出了化学研究所。Justus-Liebig大学的生命科学领域将通过与强大的合作伙伴的进一步发展和合作来扩大和支持。例如，Justus Liebig大学和新项目组"生物资源"的创新和面向未来的研究领域"昆虫生物技术"的目标是确定用于医学、作物保护或食品生物技术的家养昆虫中的新活性物质。在这种情况下，所要求的700 MHz NMR光谱仪使我们能够在新的研究领域开展工作，从而为大学内外的进一步合作奠定基础，这大大提高了Justus Liebig大学在结构分析领域的竞争力。

High-resolution NMR spectroscopy is one of the most important modern analytical instruments in chemistry. There is currently an urgent need for action in this area at the Justus Liebig University to acquire a modern 700 MHz NMR spectrometer with an N2-cooled probe head, to improve the currently insufficient detection sensitivity when measuring small amounts from synthesis and natural product isolation and when measuring less sensitive hetero-nuclei with small amounts of substance. The NMR department of the Institute of Organic Chemistry is the only department of its kind within the university and is therefore responsible for all measurements, including those from related fields. Access to high-performance NMR analysis is essential for many working groups, for whom NMR spectroscopy is of central importance. At the moment, the sensitivity and resolution of our largest NMR spectrometer (600 MHz) are only conditionally sufficient to carry out the structure elucidation of the smallest amounts of substances and poorly soluble compounds. In particular, the probe head configuration of our largest NMR spectrometer, a 5 mm broadband probe head with automatic tuning (ATM, 13 years old and often in need of repair) and a 5 mm triple resonance inverse probe head without automatic tuning is too insensitive for the investigation of small amounts and analyses of natural product isolates. Also, suppression of solvents and lengthening of measuring times are not efficient enough for a complete structural analysis of very small quantities. A 700 MHz NMR spectrometer with an N2-cooled probe head would allow, due to its higher resolution and sensitivity, the smallest amounts of substances and poorly soluble compounds to be investigated, which can only be processed inadequately with the available equipment. The requested device is also of crucial importance for the maintenance and expansion of our competencies in the field of NMR structure analysis, also beyond the institutes in chemistry. The life sciences profile area of the Justus-Liebig University is to be expanded and supported through further development and cooperation with strong partners. For instance, the aim of "Insect Biotechnology" as an innovative and future-oriented research field of the Justus Liebig University and the new project group "Bioresources" is to identify new active substances in domestic insects that are used in medicine, crop protection or in food biotechnology. In this context, the requested 700 MHz NMR spectrometer enables us to work on new research areas and thus create the basis for further cooperation within and outside the university, which greatly increases the competitiveness of the Justus Liebig University in the field of structural analysis.