Approach for bone replacing apaite cement

本研究的目的是探索在较短时间内开发可替代骨的磷灰石骨水泥（aci）的可行性。首先，将破骨细胞置于常规AC （c-AC）、快凝AC （fs-AC）、抗冲蚀AC （aw-AC）表面孵育。烧结磷灰石和皮质骨作为对照材料。我们发现破骨细胞吸收AC，即使在烧结灰石表面没有形成吸收凹坑。然而，与皮质骨相比，骨吸收面积要小得多。根据AC的类型，没有发现明显的差异，表明所有AC都会以相同的速度被骨取代。为了加速AC与破骨细胞的吸收，我们将碳酸盐离子引入AC中，碳酸盐的含量达到6%，吸收面积增加。但随着碳酸盐加入量的增加，活性炭的机械强度降低。我们观察了AC表面成骨细胞的分化情况，发现AC对成骨细胞的分化有促进作用。因此，我们得出结论，有很好的机会制造磷灰石水泥，可以在相对较短的时间内用bon代替。

The aim of this research is to find out the feasibility of the development of apatite cement (AC) that could replace with bone in relatively short period. First, osteoclasts were incubated on the surface of set conventional AC (c-AC), fast-setting AC (fs-AC) anti-washout AC (aw-AC). Sintered apatite and cortical bone were also used as reference materials. We found osteoclasts resorped AC even though osteoclasts formed no resorption pits on the surface of sintered apaite. However, the area of resorption was much smaller when compared with that of cortical bone. No significant difference was found based on the type of AC indicating that all AC would be replaced with bone in the same rate. To accelerate the resorption of AC with osteoclasts, we then introduced carbonate ion into AC.The resorption area increased with contents of carbonate upto 6%. However the mechanical strength of AC decreased with increase in the amount of added carbonate. With respect to the bone formation that should occur after resoption of AC with osteoclasts, we evaluated differentiation of osteoblasts on the surface of AC.We found AC enhance the differentiation of osteoblasts. We therefore concluded that there is a good chance to fabricate apatite cement that could be replaced with bon in relatively short periods.