Effect of Mild Exercise on Non-Insulin Mediated Glucose Uptake

1.单次运动(15m/min、90min、跑台跑)后3h，非胰岛素介导的葡萄糖摄取无明显变化。然而，经过5周的运动训练后。(4天/周，15~25m/min，60min/d)，非胰岛素介导的葡萄糖摄取显著增加(葡萄糖输注率：对照组6.5±0.8，运动8.5±1.5 mg/kg/min，p&lt；0.01)。2.采用最小运动模型研究了单次温和运动对青年男性血糖效应值(S_G)和胰岛素敏感性(S_1)的影响。在乳酸阈值下进行一次功率自行车运动60min后，S_1无明显变化，而S_G显著升高(0.016±0.002比0.025±0.002分钟)。单次轻度运动后，S血糖立即升高，与受试者训练后的水平相近。3.健康男性(18-25岁)分别在60min/d、5d/wk、6周的负荷训练前和训练6周后，进行S G型负荷试验。轻度运动训练使S_G由0.018±0.002提高到0.024±0.001。训练后S_1也显著升高(P&lt；0.05)。因此，通过温和的运动训练，不仅提高S_1，而且提高S_G，被认为是预防糖耐量异常的有效方法。4.我们为糖尿病患者开创了使用长凳的台阶测试和使用小卡路里计数器的步行测试。超过90%的情况下，乳酸盐阈值可以使用这些测试来确定。因此，这些简单的运动测试将有助于评估有氧能力，并为糖尿病患者开出运动处方。

1. The non-insulin mediated glucose uptake did not change 3 h after the single bout of exercise (15 m/min, 90 min, treadmill running). However, after 5-wk exercise training. (4day/wk, 15〜25 m/min, 60 min/day ), the non-insulin mediated glucose uptake significantly increased (Glucose infusion rate : Control 6.5±0.8, Exercise 8.5±1.5 mg/kg/min, p<0.01). 2. The effect of a single bout of mild exercise on glucose effectiveness (S_G) and insulin sensitivity (S_1) was studied in young men using a minimal model. After a bout of exercise on a cycle ergometer at the lactate threshold level for 60 min, S_1 did not significantly change, whereas the S_G significantly increased (0.016±0.002 vs. 0.025±0.002 min^<-1>, P<0.01). The increase in S^G immediately after a single bout of mild exercise is similar to the level in trained subjects. 3. Healthy men (18-25 yr.) were studied on S^G, before and after the ergometer training at lactate threshold intensity for 60 min/day, 5 days/wk for 6 weeks. The mild exercise training improves S_G, from 0.018±0.002 to 0.024±0.001 min^<-1> (P<0.05). S_1 also significantly increased after the training regimen (P<0.05). Improving not only S_1 but also S_G through mild exercise training is thus considered to be an effective method for preventing glucose intolerance. 4. We originated the step test using benches and walking test using small calorie counters for patients with diabetes. More than 90% of the cases, lactate threshold can be determined using these tests. Therefore, these simple exercise tests would be useful for evaluating aerobic capacity and making out exercise prescriptions for patients with diabetes.