Functional ubiquitination of neuronal voltage-gated sodium channels

可兴奋细胞的电特性的改变发生在组织损伤和再生以及许多疾病状态期间。预防或控制这些变化是一个关键的战略治疗目标。然而，只有通过对调节细胞兴奋性的分子机制的全面理解，我们才能确定这些治疗靶点。该项目的主要成果将是对一种新途径的彻底表征，这种途径在神经系统的发育，稳态和再生中可能至关重要。该系统正常功能的破坏可能是在甘露醇神经退行性疾病中观察到的过度兴奋的基础。

Alterations in the electrical properties of excitable cells occur during tissue injury and regeneration as well as many disease states. Preventing or controlling these changes is a key strategic therapeutic aim. It is, however, only through a comprehensive understanding of the molecular mechanisms that regulate cellular excitability that we can identify these therapeutic targets. The major outcome of this project will be a thorough characterisation of a novel pathway that is potentially crucial in the development, homeostasis and regeneration of the nervous system. Disruption of normal function of this system may underlie the hyperexcitability observed in mannu neurodegenerative conditions.