Research on spectrotomography inside skin by supercontinuum white light

本研究工作的目的是发展一种产生稳定的超连续谱白光光源的方法，并证明利用超连续谱白光光源重建人体皮肤内光谱层析图像的可行性。1）超连续谱白光光源阵列为了利用钛宝石激光产生稳定的超连续谱白光光源，我们尝试利用微透镜阵列产生超连续谱白光光源阵列，并成功地同时产生了约100个超连续谱白光光源。我们还利用时间分辨的纹影光学观测研究了产生超连续白光光源的灯丝形成的统计特性。2）超连续白光空间相干性的研究 ...更多信息 并且测量到极高的空间相干性。我们还通过实验证明了在液体和固体中形成的多个细丝中的两个细丝中产生的光之间的高空间相干性，这是由Ti ; Sapphire超短激光脉冲的单个光束形成的。3）光谱层析我们建立了一个非色散和色散相干光谱层析系统，其同时测量物体内部的空间和光谱信息。该系统利用超连续谱白光光源作为光源。我们评估了系统的分层介质的空间分辨率极限，光谱分辨率，信噪比。通过对虾类样品的检测，对色散相干层析成像系统进行了评价。我们成功地获得了清晰的虾尾光谱层析图像。但是，由于超连续白光光源的不稳定性，无法进行对人体皮肤的应用实验，其结果发表了一部分（Optical Review ; 1999，Japanese Journal of Applied Physics ; 2001），也发表了评论论文（Optical Review ; 2000，Japanese Journal of Optics ; 2000）。其余结果正在准备出版。少

The purpose of this research work is to develop a method to generate stable supercontinuum white-light sources and to prove *e feasibility of reconstructing spectrotomographic images inside human skin using the supercontinuum white-light sources. The results obtained in the researchare listed below.1) Array of supercontinuum white-light sourcesTo generate stable supercontinuum white-light sources by using the Ti : Sapphire laser light, we attempted to generate an array of supercontinuum white-light sources by use of a microlens array and succeeded in generating approximately 100 supercontinuum white-light sources simultaneously. We also investigated the statistical characteristics of formation of the filaments that generate the supercontinuum white-light sources by time-resolved Schlieren-optics observation.2) Study of spatial coherence of supercontinuum white-lightThe optical coherence between the elementary sources in the array of supercontinuum white-light sources has been studied a … More nd extremely high spatial coherence was measured. We also showed experimentally that the high spatial coherence between the lights generated in two filaments of the multiple filaments that are formed in the liquid and solid by a single beam of the Ti ; Sapphire ultrashort lasers pulses.3) SpectrotomographyWe built a non-dispersive and a dispersive coherence spectrotomography systems that measure simultaneously the spatial and spectral information inside the object. The systems make use of the supercontinuum white-light source as a light source. We evaluated the systems in terms of spatial resolution limit of layered media, spectral resolution, signal-to-noise ratio. The dispersive coherence spectrotomograpy system was evaluated by applying the system to small shrimps. We succeeded in obtaining clear spectrotomography image of the tail of shrimp. Due to the instability of supercontinuum white-light source, however, the application experiments to human skin could not committed.The results of this research were partly published (Optical Review ; 1999, Japanese Journal of Applied Physics ; 2001) and review papers were also published (Optical Review ; 2000, Japanese Journal of Optics ; 2000). The rest of the results are under preparation for publication. Less