Thermosensitive polymers prepared from N-vinylacylamide

我们开发了n -乙烯基异丁基酰胺（NVIBA）等新型热敏聚合物，并与聚n -异丙基丙烯酰胺（PNIPAAm）进行了性能和应用对比研究。首先，我们合成了n -乙烯基酰胺单体，并采用自由基聚合技术进行了聚合。制备了水溶性聚合物和交联水凝胶，并与PNIPAAm进行了热敏性能对比研究。A发现PNVIBA的最低温度急剧上升至39℃。苯乙烯与PNIPAAm或PNVIBA高分子单体通过自组装机制进行分散共聚得到水分散核-电晕型高分子纳米球。铂和银胶体被有效地包裹在热敏聚合物纳米球的表面（即电晕）上，在铂胶体的情况下充当氢化催化剂。当肽被物理固定在纳米球的电晕中时，从动物实验的结果来看，该系统似乎是一个设计良好的口服肽药物传递系统。最后，我们澄清了市售的n -乙烯基甲酰胺或n -乙烯基乙酰胺与乙烯乙酸酯共聚得到热敏聚合物以及PNIPAAm和PNVIBA。

We have developed novel thermosensitive polymers consisting of N-vinylacylamides such as N-vinylisobutyramide (NVIBA) and studied their properties and application comparing with poly (N-isopropylacrylamide) (PNIPAAm). First, we synthesized N-vinylacylamide monomers and polymerized using a free radical polymerization technique. After preparing water soluble polymers and cross-linked hydrogels, their thermosensitive properties were studied in comparison with PNIPAAm. It is A found that LCST of PNVIBA is sharply 39 ℃. Dispersion copolymerization of styrene and PNIPAAm or PNVIBA macromonomers gave water dispersible core-corona type polymeric nanospheres by self-assembling mechanism. Platinum and silver colloids were effectively entrapped on the surfaces (that is corona) of thermosensitive polymeric nanospheres to act as catalyst for hydrogenation in case of platinum colloids. When peptides were physically immobilized in corona of nanospheres, this system seemed to be a well-designed oral peptide drug delivery system from the results of animal examinations. Finally, we clarified that commercially available N-vinylformamide or N-vinylacetoamide were copolymerized with vinylacetate to give thermosensitive polymers as well as PNIPAAm and PNVIBA.