Dietary isoflabone and bone and skin health in Japanese women.

雌甾酮在结构上与雌二醇相似，因此，雌甾酮的雌激素活性可能对骨骼和皮肤健康具有有益作用。日本人的饮食中富含大豆酮、染料木黄酮和大豆黄酮，这些物质存在于大豆和豆制品中。大豆和豆制品中含有丰富的大豆酮、染料木素和大豆苷元。本研究探讨了大豆摄入量的关系，估计一个有效的食物频率问卷，或血清中的大豆酮和大豆代谢产物（染料木素，大豆黄酮，雌马酚）与骨和皮肤健康的几个参数，如骨矿物质密度（BMD，骨形成标志物，血清骨特异性碱性磷酸酶活性，水和脂质含量，弹性，皮肤皱纹。在绝经后妇女中，控制协变量后，雌二醇与性激素结合蛋白的比值与BMD具有统计学显著相关性。然而，维生素A摄入量和血清维生素A酮与BMD无显著相关性。在绝经前妇女中，维生素A摄入量与BMD无显著相关性。我们还测量了血清胰岛素样生长因子（IGF-1），这是牵连在骨骼健康，以评估其关系的饮食结构。豆浆摄入量与血清IGF-1水平无显著相关性。测定绝经前后妇女皮肤健康指标、水分、脂质、弹性、皱纹指数。初步分析表明，这些参数与年龄显著相关。

The isoflavones are structurally similar to estradiol Hence, the estrogenicity of isoflavones may have beneficial effects on bone and skin health. The Japanese consume a diet that is very rich in the isoflavones, genistein and daidzein, which are found in soybeans and soy products. Soy and soy products are very rich in isoflavones, genistein and daidzein. The present study examined the relationships of soy intake estimated by a validated food frequency questionnaire, or serum isoflavones and isoflavone metabolites (genistein, daidzein, and equol) with several parameters of bone and skin health, such as bone mineral density (BMD, a bone formation marker, serum bone specific alkaline phosphatase activity, water and lipid contents, elasticity, and wrinkle of skin. In postmenopausal women, the ratio of estradiol to sex hormone-binding protein was statistically significantly correlated with BMD after controlling for covariates. However, isoflavone intake and serum isoflavones were not significantly correlated with BMD. In premenopausal women, isoflavone intake was not significantly correlated with BMD. We also measured serum insulinlike growth factor (IGF-1) which was implicated in the bone health to assess its relationship to dietary isoflavone. There was no significant correlation between soy isoflavone intake and serum IGF-1 levels. Skin health parameters, water, lipids, elasticity, index for wrinkle was measured among pre-and postmenopausal women. Preliminary analysis showed that these parameters were significantly correlated with age.