Dietary isoflabone and bone and skin health in Japanese women.

异黄酮在结构上与雌二醇相似，因此，异黄酮的雌激素活性可能对骨骼和皮肤健康有有益的影响。日本人的饮食中富含大豆和大豆制品中含有的异黄酮类、染料木素和大豆苷元。大豆和大豆制品富含异黄酮类、染料木素和大豆苷元。本研究探讨了大豆摄入量和血清异黄酮类及异黄酮代谢物(染料木素、大豆苷元和马儿茶素)与骨和皮肤健康的几个参数的关系，如骨密度(骨形成标志物)、血清骨碱性磷酸酶活性、水分和脂肪含量、弹性和皮肤皱纹。在绝经后妇女中，在控制协变量后，雌二醇与性激素结合蛋白的比率与骨密度显著相关。而异黄酮类摄入量和血清异黄酮类与BMD无显著相关性。在绝经前妇女中，异黄酮类的摄入量与BMD没有明显的相关性。我们还检测了与骨骼健康有关的血清胰岛素样生长因子(IGF-1)，以评估其与饮食异黄酮的关系。大豆异黄酮摄入量与血清IGF-1水平无显著相关性。对绝经前和绝经后妇女的皮肤健康参数、水分、血脂、弹性、皱纹指数进行了测量。初步分析表明，这些参数与年龄显著相关。

The isoflavones are structurally similar to estradiol Hence, the estrogenicity of isoflavones may have beneficial effects on bone and skin health. The Japanese consume a diet that is very rich in the isoflavones, genistein and daidzein, which are found in soybeans and soy products. Soy and soy products are very rich in isoflavones, genistein and daidzein. The present study examined the relationships of soy intake estimated by a validated food frequency questionnaire, or serum isoflavones and isoflavone metabolites (genistein, daidzein, and equol) with several parameters of bone and skin health, such as bone mineral density (BMD, a bone formation marker, serum bone specific alkaline phosphatase activity, water and lipid contents, elasticity, and wrinkle of skin. In postmenopausal women, the ratio of estradiol to sex hormone-binding protein was statistically significantly correlated with BMD after controlling for covariates. However, isoflavone intake and serum isoflavones were not significantly correlated with BMD. In premenopausal women, isoflavone intake was not significantly correlated with BMD. We also measured serum insulinlike growth factor (IGF-1) which was implicated in the bone health to assess its relationship to dietary isoflavone. There was no significant correlation between soy isoflavone intake and serum IGF-1 levels. Skin health parameters, water, lipids, elasticity, index for wrinkle was measured among pre-and postmenopausal women. Preliminary analysis showed that these parameters were significantly correlated with age.