Respiratory and Cardiovascular Activation at Arousal from Sleep

从睡眠中唤醒，无论多么短暂，都与呼吸和心脏系统的活动增加有关。在正常情况下，这种反应被认为是适应性的。然而，在睡眠障碍中，个体经常醒来并且他们的睡眠是支离破碎的，例如阻塞性睡眠呼吸暂停，这种现象与高血压有关。虽然睡眠片段化的临床后果现在很明显，但导致每次唤醒时生理活动增加的机制尚不清楚。该项目的目的是深入了解产生激活反应的机制，并为最大限度地减少睡眠障碍的心脏后果提供基础。

An arousal from sleep, no matter how brief, is assciated with increased activity in the respiratory and cardiac systems. Under normal circumstances the response is considered adaptive. However, in disorders of sleep in which individuals arouse frequently and their sleep is fragmented, such as in Obstructive Sleep Apnea, the phenomenon has been linked to hypertension. While the clinical consequences of sleep fragmentation are now apparent, the mechanism that causes the increase in physiological activity at each arousal, is not known. The aim of this project will provide insight into the mechanism that produces the activation response and provide a basis for minimising the cardiac consequences of sleep disorders.