The role of pandemic and individual vulnerability in longitudinal cohorts across the life span: refined models of neurosociobehavioral pathways into substance (ab)use?

个人对危险行为的决定，如物质消费，受到神经行为微观状态的影响，包括冲动或适应不良的应激反应。然而，这些决定也被归因于社会情感线索——从宏观社会规范和机会，包括访问路线或私人空间，到中观社会因素，包括与消费同伴的亲密程度或家庭压力。COVID-19大流行在每个年龄段的不同装备的个体中引发了许多社会功能的限制和变化，我们可能需要完善先前确定的用于药物使用预测的规范性和非规范性冒险轨迹。利用现有的纵向队列研究（IMAGEN、ROLS、MARS）和横截面拟合的高分辨率实时实时数据（IMAC-Mind），在封锁期间增加了与COVID-19相关的健康/社会行为评估，我们将进行多变量分析，估计COVID-19下措施的稳定性及其随时间的关系。我们将评估样本中新的大脑和日常基于传感器的行为数据，以捕获风险/感知，纵向锁定后，以及情感调节（正念）的关键特征，并交叉验证年龄数据。确定为保护性分类因素的因素可能减弱或加强，新的关键机制关联可能出现，包括更强的性别差异。我们可以在人的一生中适当的时期对流行病对健康的影响获得宝贵的见解。

Individual decisions for risky behavior, such as substance consumption, are influenced by neurobehavioral microstates, including impulsivity or maladaptive stress reactivity. These decisions have, yet, also been attributed to socioaffective cues - from macrosocial norms and opportunities, including access routes or private space, to mesosocial factors, including closeness to consuming peers or amount of familial stress. The COVID-19 pandemic provoked many restrictions and changes in social functioning along differently equipped individuals in every age cohort, and we might need to refine previously identified normative and nonnormative risk-taking trajectories for substance use prediction. Capitalizing on existing longitudinal cohort studies (IMAGEN, ROLS, MARS) and cross-sectionally fitted high-resolution real-life momentary data (IMAC-Mind), where COVID-19-related health/sociobehavioral assessments have been added during the lockdown, we will perform multivariate analyses estimating the stability of measures under COVID-19 and relations over time. We will asses new brain and daily, sensor-based behavioral data in the samples to capture risk-taking/perceptions, longitudinally after-lockdown, and key features of affect regulation (mindfulness) and cross-validate age data. Factors established as protective classifiers might weaken or strengthen and new key associations of mechanisms might exhibit, including even stronger gender differences. We may gain valuable insight into pandemic health consequences in sensible periods along the life span.