Dynamics of stress-homeosurveillance and its relevance to disease control

重要的稳态监视是通过压力传感器接收输入信号并将输出信号发送到代谢和免疫系统来执行的。本研究通过阐明生理状态和疾病模型中疼痛、机械和氧化应激等应激感受信号输入下丘脑等重要脑中枢的信号机制和免疫、炎症和骨代谢系统等脑中枢信号输出机制，阐明稳态监测的动态性。通过PTH/PTHrP和合成神经元的输出信号致力于干细胞或幼稚细胞向特定方向分化，这参与了疾病过程。此外，使用疾病模型的结果，其中的动态自我调节调节将带来新的疾病控制策略。

Vital homeosurveillance is performed by receiving input signals through stress-sensors and by sending output signals to metabolic and immune systems. This study has been undertaken to clarify the dynamism in homeosurveillance by elucidating (1) the input signaling mechanisms of stress-sensing such as pain, mechanic and oxidative stress to vital brain centers including hypothalamus and (2) the output signaling mechanisms from brain centers to immune, inflammatory and bone metabolic systems in physiologic condition and disease models. The output signals via PTH/PTHrP and synthetic neurons commit to differentiation of stem cells or naïve cells to particular direction, which is involved in disease processes. Furthermore, results using disease models in which the dynamism in homeosuriveillance was regulated would bring novel strategies of disease control.