Numerical investigation of signal mechanotransduction of bone cells - application to bone remodeling

对骨细胞的信号机械转导的理解与骨重建过程的机械激活直接相关，即，骨组织的吸收和形成。了解骨重建对于开发新的骨植入物、骨孢子虫病的预后以及与微重力变化（例如太空飞行）相关的研究（仅举几个关键应用）至关重要。这项研究提案与国家主要研究重点之一密切相关，即，促进和保持良好的健康（良好的老龄化，老龄化的生产力）。该研究项目旨在了解机械诱导的负荷如何激活骨重建。

The understanding of signal mechanotransduction of bone cells is directly related to mechanical activation of bone remodeling processes, i.e., resorption and formation of bone tissue. Understanding of bone remodeling is essential for the development of new bone implants, the prognosis of osteosporosis, and studies related to changes in microgravity (e.g. space flight) to name a few key applications. This research proposal closely aligns with one of the major national research priorities, i.e., promoting and maintaining good health (ageing well, ageing productively). The research project is aimed to understand how mechanically induced loading may activate remodeling of bone.