Mechanisms of protection from SARS-CoV-2 by neutralizing and non-neutralizing monoclonal antibodies in a small animal model
Mechanisms of protection from SARS-CoV-2 by neutralizing and non-neutralizing monoclonal antibodies in a small animal model
批准号:
458682471
负责人:
Professor Dr. Klaus Überla
金额:
$0.0万
依托单位国家:
德国
项目类别:
Research Grants
财政年份:
2021
资助国家:
德国
项目状态:
已结题
起止时间:
2020-12-31 至 2021-12-31
中文摘要
SARS-CoV 2的中和性单克隆抗体已被证明在被动免疫动物的攻击后降低病毒载量。由于保护机制尚未确定,该项目旨在确定Fc效应机制是否有助于保护,以及SARS-COV-2刺突蛋白的中和和非中和抗体是否可以在体内防止接种物中的病毒感染第一个细胞。
英文摘要
Neutralizing monoclonal antibodies to SARS-CoV2 have been shown to reduce viral load after challenge of passively immunized animals. Since the mechanisms of protection have not been defined the project aims to determine whether Fc-effector mechanisms contribute to protection and whether neutralizing and non-neutralizing antibodies to the SARS-COV-2 spike protein can prevent in vivo the infection of the first cells by viruses from the inocculum.
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依托单位:
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负责人:Professor Dr. Klaus Überla
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依托单位:
国内基金
海外基金
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批准号:60970111
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项目类别:面上项目
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资助金额:33.0万元
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批准年份:2009
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负责人:陈克非
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依托单位: