Autonomic nervous functions in fetal type Minamata disease patients : assessment of heart rate variability.

为评价胎儿型水螅病（FMD）患者的心血管自主神经功能，对FMD患者进行了血压（BP）、心率变异性（HRV）时域和频域分析。受试者为9例确诊为FMD的美穗安患者和13例年龄匹配的健康对照者。利用快速傅立叶变换（FFT）进行了时域分析和频域分析。在时域分析中，FMD组的平均RR显著低于对照组。SD RR和CV在两组间均无显著性差异，但均呈下降趋势，治疗组明显低于对照组。这些结果表明，副交感神经功能障碍可能存在于FMD患者，谁暴露于高剂量的甲基汞在产前期间。

In order to assess the cardiovascular autonomic nervous functions patients with fetal type Minamata disease (FMD), we investigated blood pressure (BP), and conducted time and frequency domain analysis of heart rate variability (HRV). Subjects were 9 patients in Meisuien recognized as FMD, and 13 healthy age matched control subjects. Time domain analysis and frequency domain analysis by fast Fourier transformation (FFT) were conducted. In the time domain analysis, the mean RR of the FMD group was significantly lower than that of the control group. Neither SD RR nor CV showed significant differences between the two groups, but both tended to be lower in the group was significantly lower than that of the control group. These findings suggest that parasympathetic nervous dysfunction might exist in FMD patients, who were exposed to high doses of methylmercury during the prenatal period.