Experimental study on the application of calcium phosphate cement for endodontic treatment in pediatric dentistry.

如果有一种物质，其物理性质有利于牙科材料的使用和生物相容性，它可以比氢氧化钙（CH）更适合髓切开术的敷料。在本研究中，生物相容性。采用体外和体内评价系统研究了由八磷酸钙（OCP）和α -磷酸三钙（α - tcp）组成的新型磷酸钙水泥（CPC）的化学稳定性和促进硬组织形成的能力。第一年，将极化羟基磷灰石晶体植入大鼠胫骨骨髓，观察其促进硬组织形成的能力。结果表明，正电荷表面和负电荷表面促进硬组织形成的能力不同。因此，我们保留在新材料中使用。另一方面，由OCP和α - top分别占31%和69%组成的CPC在体外实验中表现出最有利的物理性能。因此，从该项目的第二年开始，将该CPC销售用作大鼠的牙髓封盖剂，并进行组织病理学检查。结果表明，在实验前期使用OH组修复性牙本质形成更为突出。cpp组修复牙本质的形成在盖髓后5周较为明显。此外，修复性牙本质由规则的牙本质小管组成，在基于oop的水泥组中观察到的频率更高。ocp基骨水泥在根管治疗中可能是有用的，因为它允许牙髓发生良好的愈合过程。

If there is a substance which has physical propaties favorable for use in dental material and biocompatibility, it can be more suitable for the dressing of pulpotomy than calcium hydroxide (CH). In the present study, biocompatibility. chemical stability, and ability to promote hard tissue formation of a new calcium phosphate cement (CPC) setting composed of octacalcium phosphate (OCP) and alpha-tricalcium phosphate (alpha-TCP) are examined using in vitro and in vivo assessment systems.In the first year, polarized hydroxyapatite crystals were implanted in to bone marrow of rat tibiae to examine its ability to promote hard tissue formation. The results showed that the abilities to promote hard tissue formation were different between positively charged surface and negatively charged surface. We, therefore, reserved to use in the new material. On the other hand, a CPC which was composed of OCP and alpha-TOP in 31 % and 69 % respectively showed physical propaties most favorable for use in dental material in vitro experiments. From second year of this project, therefore, this CPC selling was used as a pulp capping agent in rats, and the tissue reaction was examined histopathologically. The results showed that the reparative dentin formation was more prominent in OH used group in the early stage of the experiment. 5 weeks after pulp capping, however, formation of reparative dentin was prominent in the CPC setting group. Furthermore, reparative dentin consisting of regular dentinal tubules was observed more frequently in the OOP-based cement group. OCP-based cement may be useful in endodontic treatment because it allowed favorable healing processes to occur in the dental pulp.