Mechanism and Optimization of Diffusion controlled enantioselective permeable membrane

我们合成了新的定义良好的聚合物，并利用这些聚合物开发了具有高对映选择性的光学分辨膜。我们认为分离发生在扩散过程中。但原因和细节尚不清楚，渗透率较低。在本研究中，对这些膜工艺进行了若干优化。例如，对分子结构、膜制备条件和渗透进行了考察。首先，合成了几种新的光学活性聚合物。特别是，我们发现了新的聚合方法来获得手性螺旋聚合物。此外，通过缩聚法制备了新的手性螺旋聚合物。其次，我们证实了这些膜的分离过程发生在扩散过程中。此外，还发现手性螺旋对对映选择性渗透是有效的。特别地，我们发现在膜状态下通过反应去除手性基团的聚合物膜具有对映选择性渗透性。最后，制备了复合膜和不对称膜等薄膜。利用这些薄膜实现了高渗透。渗透蒸发也被尝试使速率更高。总之，我们获得了更高的渗透率，并获得了许多实际应用的发现。

We have synthesized new well-defined polymers and developed optical resolution membranes which have high enantioselevtivity from these polymers. We proposed the separations occurred in diffusion process. However, the reason and detail were not clear and their permeation rates were low. In this study, several optimizations were carried out in these membrane process. For example, molecular structures, conditions in membrane preparation and permeation were examined.First, several new optically active polymers were synthesized. Especially, we have discovered new polymerization method to obtain chiral helical polymers. In addition, new chiral helical polymers were prepared by condensation polymerization.Secondly, we confirmed the separation of these membrane process occurred in diffusion process. In addition, chiral helicity was found to be effective for enantioselective permeation. In particular, we found that polymeric membranes whose chiral groups had been removed by reaction in membrane state showed enantioselective permeability.Lastly, thin membranes such as composite membranes and asymmetric membranes were prepared. High permeation was realized by using these thin membranes. Pervaporation was also tried to make the rate higher.In conclusion, we attained higher permeability and obtained many findings for practical use.