Detection of Spinal Cord Injury during Thoracoabdominal Aortic Aneurysm Surgery Using Multi-channel Superconducting Quantum Interference Device

本课题的主要目的是测试超导量子干涉仪（SQUID），用于检测脊髓传导和预测脊髓缺血。(1)脊髓研究用SQUID系统的开发（广岛大学）：使用单通道SQUID检测脊髓作用磁场失败。单通道器件性能的局限性是这一失败的深刻原因。(2)脊髓缺血模型：缺血诱导成年犬交叉夹胸主动脉60分钟。2002年4月，我们开始研究使用高性能71通道SQUID在NTT Docomo多媒体实验室（横须贺，日本）。该多通道装置给出了如下结果。(3)周围复合神经作用磁场（CAF）的测量及其空间分析：我们成功地测量了人体正中神经和尺神经的CAF。神经传导通过磁图可视化。(4)Magne ...更多信息 缺血性神经传导障碍的分析：我们成功地用磁研究记录了正中神经传导的缺血性改变。用充气止血带绕上臂造成前臂缺血20 min，正中神经CAF波幅在缺血开始后5 min显著增高，20 min逐渐降低，几乎完全消失，磁图检查也显示缺血早期特征性改变。(5)脊髓多导SQUID系统的研制：（1）兔脊髓作用磁场的研究我们成功地显示了脊髓上行传导仅在腰区的磁研究。B）-犬研究;由于传感器灵敏度不足，我们未能记录犬脊髓的磁场。如果这个问题得到解决，我们将应用一个缺血协议来测试当前的多通道设备，以检测脊髓缺血。少

The main purpose of the current project was to test superconducting quantum interference device (SQUID), for detecting the spinal cord conduction and for predicting spinal cord ischemia. (1) Development of SQUID system for spinal cord study (at Hiroshima University) : Detection of spinal cord action magnetic field using one-channel SQUID failed. The limitation of the performance of the one-channel device was the profound cause of this failure. (2) Spinal cord ischemia model : Ischemia was induced in adult dogs by cross-clamping the thoracic aorta for 60 min.On April, 2002, we started to research using high performance 71-channel SQUID at NTT Docomo Multimedia Laboratories (Yokosuka, Japan). This multi-channel device has given results as follows. (3) Measurement of the peripheral compound nerve action magnetic field (CAF) and its spatial analysis : We succeeded in measuring the CAF of the human median and ulnar nerves. Nerve conduction was visualized by means of magnetography. (4) Magne … More tic analysis of ischemia-induced nerve conduction impairment : We succeeded in recording ischemic- changes of the median nerve conduction with magnetic study. Twenty -minute fore-arm ischemia was induced with the pneumatic tourniquet placing around the upper arm. The amplitude of the CAF of the median nerve significantly increased at 5 min after the initiation of ischemia, and it gradually decreased and almost completely disappeared at 20 min. Magnetographic evaluation also showed characteristic findings during early period of ischemia. (5) Development of multi -channel SQUID system for spinal cord study : A)-Spinal cord action magnetic field in rabbit ; We succeeded in visualization of ascending spinal cord conduction only in the lumbar area with magnetic study. B)-Dog study ; We failed to recording magnetic field of the canine cord because of insufficient sensor sensitivity. If this trouble is solved, we will apply an ischemia protocol for testing the current multi-channel device to detect spinal cord ischemia. Less