Fundamental verification to establish evidences among pulmonary rehabilitation.

1)通过改变传统上认为的呼吸模式，观察缩颈呼吸(PLB)对支气管扩张和呼吸效率的影响，对10名健康受试者在PLB期间进行了呼吸力学测试。我们在2004年的ATS会议上报告了PLB期间的呼吸阻抗和鼻咽闭合，并提交发表。此外，还对COPD患者进行了测量。结果显示了PLB期间的各种变化，这些结果将在2005年日本呼吸护理学会和2005年美国胸科医师学会上报告，并将提交。计划在PLB期间进行脑电研究，以检测其对健康受试者和COPD患者呼吸困难感觉的影响。我们基本完成了对脑电α波进行频谱分析的数据获取工作。目前，分析工作正在进行中。我们还在研究体外循环期间心电图R-R变化的数据，但还没有完成。2)我们新开发了…胸部理疗前后呼吸肌耗氧量测量的“死腔负荷系统”该系统可在不受功能残存容量影响的情况下测量呼吸肌耗氧量，适用于慢性阻塞性肺疾病患者。该系统已经申请了专利。对COPD患者进行胸部理疗前后的组织氧饱和度测定。3)研究肋间肌组织氧饱和度，探讨呼吸肌训练的最佳负荷。但是，由于技术上的困难，我们决定将评估的对象改为呼吸附件肌，并继续进行实验。4)由于医院的问题，无法在PLB过程中使用电子束CT拍摄肺部图像。初步图像已经发表在《新英格兰医学杂志》上。利用电子束CT研究PLB期间的支气管化效应的联合项目正在与志贺医科大学进行。较少

1)To examine the effects of Pursed hp breathing (PLB) on broncho-dilation and improvement of respiratory efficiency by changing respiratory pattern which have been historically assumed, ventilatory mechanics was measured in 10 healthy subjects during PLB. We reported respiratory impedance and nasopharyngeal closure during PLB at ATS meeting 2004 and submitted for publication. Further, the measurements were also performed in the patients with COPD. The results showed various changes during PLB, which will be reported at Japanese Society for Respiratory Care 2005 and American College of Chest Physicians 2005, and will be submitted. EEG study during PLB were planned to examine the effects on dyspnea sensation in healthy subjects and patients with COPD. We almost finished to obtain the data to performm frequency analysis of EEG alfa-wave. Currently, the analysis is undergoing. The data concerning R-R variation in ECG is also being studied during PLB, but not finished, yet.2)We newly develo … More ped "Dead space loading system" to measure oxygen consumption of respiratory muscle before and after chest physiotherapy This system allows to measure the oxygen consumption without influence of functional residual capacity, and is suited for patients with COPD. A patent was already applied for the system. The preliminary studies were done, and the measurement will be started in the patients with COPD before and after chest physiotherapy.3)We tried to study tissue oxygen saturation in intercostals muscles to investigate the optimal load for respiratory muscle training. However, because of technical difficulties, we decided to change the target of the assessment to respiratory accessory muscles and to continue to do experiments.4)It became impossible to take image of the lung during PLB using electron-beam CT because of the problem in the Hospital. The preliminary images were already published in New England Journal of Medicine. Joint projects to study bronch-dailating effects during PLB using electron-beam CT is under processing with Shiga Medical University. Less