Development of novel types of bone-like polymer-ceramics composites using self-organized patterns

本研究项目旨在提出制备具有三维分级结构的聚合物-陶瓷复合材料的新途径，并开发新型生物活性材料。本课题的研究成果分为两部分：以无机晶体在凝胶基质中的自组织空间图案化研究为模型案例，利用凝胶基质中的空间图案化方法制备层次化和纳米结构的羟基磷灰石及其复合材料。在本项目的第一部分中，我们发现凝胶基质中质量传输的控制和有机分子在无机晶体特定表面的吸附是无机晶体自组织空间图案的基本因素。此外，无机晶体和有机胶凝剂之间的强相互作用产生了从纳米到宏观的层次化组织结构。这些发现在受控…中是有效的由于天然生物矿物也是由类似于人工系统的纳米级构建块组成的，因此更多地合成了具有三维结构的新型有机-无机复合材料。在本项目的第二部分，我们开发了一种新型的羟基磷灰石-聚合物复合材料，其结构类似于天然骨的层次结构。该反应条件成功地控制了HAP的宏观周期结构，使其由层状结构变为孔状结构。层状羟基磷灰石-聚合物复合材料具有与天然骨相似的力学性能，具有潜在的新型生物相容性材料。本研究还提供了通过前驱体晶体的拓扑定向转变来形成层次化结构的另一条制备路线。通过含有明胶分子的磷酸氢钙的拓扑定向转变，成功地制备了新型的纳米织构和纳米纤维羟基磷灰石。以脱水法制备的纳米磷酸氢钙为原料，通过与明胶分子的特异性相互作用，形成了具有约20 nm颗粒取向骨架的纳米结构羟基磷灰石和沿c轴拉长的直径约为50 nm的纳米纤维状羟基磷灰石。具有高比表面和宏观孔的纳米结构羟基磷灰石的层次化结构将适用于各种生物医学应用。这种层次化的多孔羟基磷灰石结构可用作组织工程的吸附剂和支架。较少

This research project aimed proposal of novel routes for preparation of polymer-ceramic composite materials having three-dimensionally hierarchical structures and development of new types of bioactive materials. The results of this project is categorized into two parts ; study of self-organized spatial pattern of inorganic crystals in gel matrix as model cases for various practical materials and preparation of hierarchical and nanostructures hydroxyapatite and its composite materials using the spatial patterning in gel matrix.In part I of this project, we found that the control of mass transport in gel matrix and the adsorption of organic molecules specific on specific surfaces of inorganic crystals the essential factors for the self-organized spatial patterns of inorganic crystals. Moreover, the strong interaction between inorganic crystals and organic gelling agents produced hierarchically organized architecture from nano to macroscale. These findings are effective in the controlled … More synthesis of new types of organic-inorganic composite having three-dimensional structures because natural biominerals are also composed of nanoscale building blocks similar to the artificial system.In part II of this project, we developed a new type of hydroxyapatite-polymer composite having a hierarchically organized architecture similar to that of natural bone. The macroscopic periodic structure of HAp was successfully controlled from laminated layers to a cellular porous form by the reaction condition. The laminated HAp-polymer composites have potential for new types of biocompatible materials, because their mechanical properties are similar to those of natural bone. This study also provided another preparation route through the topotactic transition of precursor crystals for the formation of a hierarchical architecture. Novel types of nanotextured and nanofibrous hydroxyapatite were successfully produced through the topotactic transition of dicalcium phosphate dehydrate containing gelatin molecules. Nanotextured hydroxyapatite with an oriented framework of ca. 20 nm grains and nanofibrous hydroxyapatite elongated along the c axis with a diameter of ca. 50 nm were formed from nanostructured dicalcium phosphate prepared by dehydration through the specific interaction with gelatin molecules. The hierarchical architectures of the nanostructured hydroxyapatite providing a high specific surface and macroscopic pores would be applicable for various biomedical applications. The hierarchical porous hydroxyapatite architectures could be useful as an adsorbent and as a scaffold for tissue engineering. Less