Follow-up study on changes of plasma fibrinogen in relation to cardiovascular risk factors in lifestyle-related diseases

最近的证据表明，血浆纤维蛋白原水平是心血管疾病的独立危险因素。作者于2000年对2,800例健康体检者进行了血浆纤维蛋白原测定。本研究于2003年对同一地区2,587人进行了血浆纤维蛋白原检测。其中1 812人在2000年和2003年接受了健康检查。在排除脑血管病、心脏病和糖尿病的情况下，分析了1，620人，以探讨心血管危险因素对2000年至2003年血浆纤维蛋白原水平三年变化的影响。纤维蛋白原水平的三年变化与年龄、BMI、总胆固醇和HbAlc呈正相关，与HDL-胆固醇呈负相关。目前的纵向研究表明，有心血管危险因素的人很可能有一个更大的血浆纤维蛋白原在未来的增加。

Recent evidence has shown that plasma fibrinogen levels are an independent risk factor for cardiovascular diseases. The authors measured plasma fibrinogen from about 2,800 attendants in annual health examination in 2000. In this study, we examined plasma fibrinogen of 2,587 persons in the same place in 2003. Of them, 1,812 persons underwent health examinations in both 2000 and 2003. Excluding those with cerebrovascular diseases, heart diseases and diabetes mellitus, 1,620 persons were analyzed to investigate the effect of cardiovascular risk factors on three-year changes in plasma fibrinogen levels between 2000 and 2003. The three-year changes in fibrinogen levels tended to be positively associated with age, BMI, total cholesterol and HbAlc, and negatively with HDL-cholesterol. The present longitudinal study suggested that persons with cardiovascular risk factors were likely to have a greater increase in plasma fibrinogen in the future.