Investigation for establishment of the indicators of alcohol intake by mean corpuscular volume, γ-GTP, and the inquiry method

(目标)在《健康日本21》中，推荐的酒精摄入量不超过1谷清酒(=22克酒精)。据报道，少量饮酒可以减少脑梗塞。尽管伽玛-谷氨酰转肽酶(γ-GTP)被认为是酒精指标，但它并不能与酒精摄入量平行，尤其是在女性中。此外，平均红细胞体积(MCV)并未被广泛用作酒精摄入量的指标。本文的目的是确定适量饮酒人群的平均红细胞压积和γ-GTP的临界值。(方法)(1)健康体检中选择年龄30~69岁的6989名健康体检者，比较不同饮酒组的平均红细胞压积和γ-GTP。(2)利用受试者工作特征曲线计算出相应酒精浓度(男性为150g，女性为100g)所对应的MCV和γ-GTP的界值。酒精是指每周的酒精摄入量，以克乙醇为单位。(3)研究了MCV与维生素B、叶酸的关系。结果(1)无论男女，MCV均随酒精浓度的增加而升高。在男性中，γ-GTP与酒精平行增加，但在女性中没有。(2)与适量乙醇相对应的MCV和γ-GTP的界值，男性分别为92fL/L和40IU/L，女性分别为90fL/L和17IU/L。(3)MCV与维生素B_(12)和叶酸均无相关性。(结论)(1)MCV是男性和女性酒精摄入量的指标，而γ-GTP仅是男性的指标。(2)总体来说，MCV和γ-GTP的分界值对于饮酒课是有效的。

(Objective)In Health Japan 21, the recommended alcohol intake is less than or equal to 1 gou of sake(=ethanol 22g). It is reported a little drinking reduces cerebral infarction.Although Gamma-glutamyl transpeptidase (γ-GTP) is known as an alcohol indicator, it does not parallel alcohol intake, especially in women. In addition, mean corpuscular volume(MCV) is not widely used as an indicator of alcohol intake. The purpose of this article is to determine the cut-off value of MCV and γ-GTP in the population consuming appropriate amount of alcohol. And we turned to teach the appropriate drinking method to the person without complication and disease into a purpose.(Methods)(1)Total of 6989 subjects aged 30 to 69 years were recruited during our health check-up, and MCV and γ-GTP were compared between different Ethanol groups. (2)The cut-off values for MCV and γ-GTP corresponding to the appropriate Ethanol(150 g in men, and 100 g in women) were calculated using receiver operating characteristic curves. Ethanol is alcohol intake per week expressed in gram of ethanol. (3)We examined relation of MCV and both Vitamin B_<12> and folic acid. (Results)(1)MCV elevated with the increase of Ethanol in both sex. γ-GTP in men increased parallel to Ethanol, but not in women. (2)The cut-off values for MCV and γ-GTP corresponding to the appropriate Ethanol were 92 fL/L and 40IU/L in men, and 90fL/L and 17 IU/L in women, respectively. (3)MCV was not related with both Vitamin B_<12> and folic acid. (Conclusion)(1)MCV is an indicator of alcohol intake in both sex, while γ-GTP is an indicator only in men. (2)Overall, the cut-off values for MCV and γ-GTP is effective for a drinking lesson.