The expression of endostatin /type XVIII collagen in the human endometrium and deciduas of the early pregnancy.

用抗内皮抑素/XVIII型胶原的单克隆抗体，用间接免疫荧光法研究了这种胶原在人子宫内膜中的分布。在增殖期和分泌期，内皮抑素仅定位于子宫内膜腺体的基底膜和血管壁。然而，尽管在正常早孕蜕膜的子宫内膜间质细胞的细胞周围区域中发现了内皮素/XVIII型胶原的强染色，但在自然流产的蜕膜组织中观察到非常弱或无染色。这些结果表明，内皮抑素/XVIII型胶原可能在植入，维持妊娠中发挥重要作用，这种胶原的表达减少可能与自然流产有关。

The distribution of endostatin /type XVIII collagen was investigated in the human endometrium by an indirect immunofluorescence method with specific monoclonal antibody against this collagen. Endostatin was localized exclusively in the basement membrane of the endometrial glands and in the walls of blood vessels during the proliferative and secretory phases. However, although strong staining for endoststin /type XVIII collagen was recognized in the pericellular region of endometrial stromal cells in the deciduas of normal early pregnancy, very weak or no staining was observed in the decidual tissues of spontaneous abortion. These results suggest that endostatin/ type XVIII collagen might play an important role in implantation, the maintenance of pregnancy and that decreased expression of this collagen could be associated with spontaneous abortion.