Investigation of pathologic physiology of ocular circulation disorder by using noninvasive human ocular circulation measuring apparatus

动物检查用彩色多普勒成像(CDI)对兔眼内动脉(IOA)进行血流测量。实验1：使用我们研制的测量装置，血流量测量的重复性约为7%。实验2：血压与阻力指数呈显著负相关。实验3：单次滴注5%苯肾上腺素后，血压和眼压无明显变化，RI升高。实验4：观察静脉注射激肽原酶(1.0IU/kg)对阻力指数的影响。其次，用激光多普勒测速仪(LDV)对食蟹猴视网膜动脉(RA)的血流速度进行了测量。血压与RI呈显著负相关，而局部注射ET-1后血流量有下降趋势。体检1：…测量血流速度更多关于年轻健康志愿者使用CDI的CRA和使用LDV的RA的详细信息。RI值与R值呈负相关。检查2：用彩色多普勒超声对有或无高血压家族史的健康青年志愿者及高血压患者的CRA进行血流速度测量。用血管分析仪对RA患者进行血管内径测量。有高血压家族史的年轻健康志愿者的血压和舒张期血流速度显着增加，而无高血压家族史的年轻健康志愿者的RI显着增加。服用氨氯地平5 mg的高血压病患者血压和血流速度显著降低，RA内径显著增大，RI显著增加。本研究结果表明，RI与R不对应，视网膜血管顺应性和脉搏波速度是研究全身血压和眼循环关系的重要指标。较少

Animal examinationThe blood flow measurements were performed on an internal ophthalmic artery (IOA) by using color Doppler imaging (CDI) in rabbits. Experiment 1 : Reproducibility of the blood flow measurements was approximately 7% by using our developed measuring device. Experiment 2 : There was significant negative correlation between BP and RI. Experiment 3 : There was no significant change in BP and IOP, while RI increased after a single phenylephrin (5%) instillation. Experiment 4 : The effect of Kallidinogenase (1.0 IU/kg) after venous injection on RI was evaluated. There was no significant correlation between BP and RI.Next, the blood velocity measurements were performed on a retinal artery (RA) by using laser Doppler velocimetry (LDV) in cynomolgus monkeys. There was significant negative correlation between BP and RI, while blood flow tended to decrease after endothelin-1 (local injection) injection.Human examinationExamination 1 : The blood velocity measurements were performed … More on CRA by using CDI and RA by using LDV in young healthy volunteers. There was negative correlation between RI and R.Examination 2 : The blood velocity measurements were performed on CRA by using CDI in young healthy volunteers with or without a hypertensive family history and hypertensive patients. The vascular diameter measurements were also performed on RA by using vascular analyzer. BP and diastolic blood velocity increased significantly in young healthy volunteers with a hypertensive family history whereas RI increased significantly in young healthy volunteers without a hypertensive family history were observed. BP and blood velocity deceased and RA diameter enlarged significantly while RI increased significantly in treated (amlodipine 5mg) hypertensive patients were observed.The results of present study indicate that RI dose not correspond to R, and retinal vascular compliance and pulse wave velocity are important to investigate the association between systemic blood pressure and ocular circulation. Less