Clinical Impact of Dysadherin Expression in tissue of Pancreatic Cancer obtained by biopsy and resection.

在这项研究中，我们试图通过胰腺癌患者的组织活检和切除来研究粘附异常表达的临床病理影响，这可能是人类胰腺癌的早期标志物。T Shimamura阐明了人胰腺癌细胞中粘附不良表达的细胞运动性和转移潜力（T Shimamura等人）。异常粘附蛋白的表达促进了人胰腺癌细胞的运动和转移潜能。癌症研究2004；64:689 - 695)。虽然，我们在2007年研究了ERCP与慢性胰腺炎和自身免疫性胰腺炎患者的胰液中含有癌细胞的新标记物，但很难通过内镜手术获得胰腺癌细胞。我们不能得到任何有用的和有益的结果。2008年，我们改进了我们的方法，采用FNA和内镜活检从十二指肠乳头取胰组织。结果，我们发现胰腺组织和十二指肠乳头组织中粘附不良蛋白的阳性率明显高于慢性胰腺炎患者。我们认为，在人类晚期胰腺癌的切除组织和活检标本中检测粘附不良蛋白的表达是有用的标志物。

In this study, we tried to investigate the clinicalpathological impact of dysadherin expression by using tissue obtained biopsy and resection from patients with pancreatic cancer, which could be an early marker for human pancreatic cancer. T Shimamura elucidated the cell motility and metastatic potential of dysadherin expression in the human pancreatic cancer cells (T Shimamura et al. Dysadherin expression facilitate cell motility and metastatic potential of human pancreatic cancer cells. Cancer Research 2004;64:6989-6995).Although, we studied this new marker in pancreatic juice contained cancer cells obtained while ERCP compared with patients of chronic pancreatitis and with autoimmune pancreatitis in 2007, it was difficult to obtain pancreatic cancer cells using endfoscopic procedure. We could' t get any useful and rewarding result.In 2008, we modified our method to take pancreatic tissue by using FNA and endoscopic biopsy from duodenal papilla. As a result, we found that the positivity rate of dysadherin is significantly higher in pancreatic tissue and tissue of duodenal papilla than that from patients with chronic pancreatitis. We conclude that the detection of dysadherin expression in human advanced pancreatic cancer in the resected tissues and biopsied specimens is useful marker.