A New Generation Biosensor and Fluorescence Facility for Proteomics

许多生物体的完整DNA序列（基因组）现已为人所知，在鉴定信使RNA的互补序列（转录组）和由此产生的蛋白质集合（蛋白质组）方面也取得了进展。基因组在很大程度上是固定的，而转录组和蛋白质组在生物体中的细胞类型之间不同，并且不断变化以使细胞适应变化的条件。这些变化的介质是蛋白质，它们彼此相互作用并与信号分子相互作用。分子生物学的下一个前沿是识别和量化这些蛋白质相互作用。我们的两个机构有一个非常大的生物学家群体，他们对蛋白质的研究将大大促进Biacore 3000和ISS K2。

The complete DNA sequence (the genome) is now known for many organisms and advances are being made to identify the complement of messenger RNA (the transcriptome) and the resultant collection of proteins (the proteome). The genome is largely fixed while the transcriptome and proteome differ between cell types in an organism and constantly vary to adapt the cell to changing conditions. The mediators of these variations are proteins, interacting with each other and with signal molecules. The next frontier in molecular biology is to identify and quantify these protein interactions. Our two institutions have a very large cohort of biologists whose research on proteins would be greatly facilitated by the Biacore 3000 and the ISS K2.