Interactive effect of osmoregulatory and volume regulatory stimuli on thermoregulation.

为了更好地了解体液调节系统和体温调节系统之间的相互作用，我们研究了体液调节刺激对人体体温调节反应的影响。与仰卧位相比，直立位减少了对身体核心冷却的产热反应。相反，直立姿势增强外周血管收缩。因此，对冷应激的体温调节反应受容积调节系统的影响。结果还表明，在冷应激过程中，控制外周血管收缩和产热的机制似乎是独立的。我们还研究了血浆高渗对压力感受器卸载诱导的外周血管收缩的影响。血浆高渗透压可增强热应激时下体负压引起的前臂血管传导性的降低，但在常温下无此作用。因此，在那里。血浆高渗浓度与C ...更多信息 中心性低血容量对热应激时外周血管反应的影响，但对常温时无影响。我们的研究结果表明，血浆高渗透压增强压力感受器介导的减少热活性外周血管舒张，但不增强血管收缩system.In一系列的动物实验中，我们研究了体液调节系统的中枢机制。本文用核磁共振方法结合静脉注射不能通过血脑屏障（BBB）的舒张剂Gd-DTPA_（12），定量测定了大鼠穹窿下器毛细血管通透性<2->。建议的值可能比皮质中的血液屏障大10-100倍。我们的结论是，毛细血管在SFO中有一个最高的水渗透性值之间的所有毛细血管在大脑中，这个网站可能发挥重要作用，在电子邮件接收。在另一项动物实验中，我们认为Mn^&lt;2+&gt; MRI是一种有用的技术，可用于识别活体下丘脑中对各种刺激做出反应的活跃脑区。少

To gain better insights into the interaction between fluid regulatory and thermoregulatory systems, we examined the effect of body fluid regulatory stimuli on thermoregulatory responses in human subjects.Upright posture reduced thermogenesis in response to body core cooling, compared with supine position. In contrast, upright posture enhanced peripheral vasoconstriction. Therefore, the thermoregulatory response to cold stress is influenced by volume regulatory system. The results also suggest that the mechanisms controlling peripheral vasoconstriction and thermogenesis during cold stress are appeared to be independent. We also examined the effect of plasma hyperosmolality on baroreceptor unloading-induced peripheral vasoconstriction. Plasma hyperosmolality augmented the reduction of forearm vascular conductance induced by lower body negative pressure during heat stress but not during normothermia. Therefore, there. apparently exists an interactive effect of plasma hyperosmolality and c … More entral hypovoloemia on the peripheral vascular response during heat stress, but not during normothermia. Our findings suggest that plasma hyperosmolality enhances baroreceptor-mediated reduction of thermal active peripheral vasodilation, but does not enhance the vasoconstrictor system.In a series of animal experiments, we examined the central mechanisms of the body fluid regulatory system. We quantified the permeability of capillaries in the subfornical organ of rat by a nuclear magnetic resonance method in combination with a venous injection of a relaxation reagent, Gd-DTPA^<2-> which could not pass through the blood-brain barrier (BBB). The proposed value may be 10-100 times larger than that of the blood-barrier in the cortex. We conclude that the capillaries in the SFO have one of the highest water permeability values among all of the capillaries in the brain, and this site may play an important role in osmoreception. In another animal experiment, we suggest that Mn^<2+> MRI is a useful technique for identifying in vivo the active brain region in the hypothalamus in response to various stimuli. Less