Interaction of stress defending system, thermoregulation and osmoregulation in the systemic vasopressin release

应激防御系统、体温调节和渗透压调节在全身加压素释放中的相互作用

• 批准号: 12670065
• 负责人: TAKAMATA Akira
• 金额: $ 2.05万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670065/
• 关键词: vasopressin; plasma osmolality; endotoxemia; brain angiotensin; AT1 receptor; exercise; stress; ACTH; パゾプレッシン; 食道温; 身体運動; アンギオテンシンII; 浸透圧調節; 視床下部-下垂体軸

To elucidate the interactive effect of thermal and stress stimuli and osmoregulation on systemic vasopressin secretion, we examined the effect of endotoxemia on vasopressin release and its mechanism in rats. We also examined the mechanism of vasopressin release during exercise in humans.Endotoxemia, induced by intravenous lipopolysaccharide (IPS) administration, induced vasopressin release and water ingestion behavior in rats without any changes in plasma osmolality or plasma volume. Intracerebroventricular (i. c. v.) administration of losartan (angiotensin II AT1 receptor antagonist) almost completely inhibited these responses, suggesting that the brain angiotensin II is involved in the LPS-induced systemic vasopressin secretion and thirst via AT1 receptor.To reveal the mechanism of vasopressin release during exercise in humans, we compared the relationship between plasma vasopressin concentration and plasma osmolality during a graded cycle ergo meter exercise protocol and this relati … More onship during hyper tonic saline infusion at rest. Exercise at lower intensity (< 60 % maximal oxygen uptake (VO_2max)) attenuated osmotic vasopressin secretion, and exercise at higher intensity (> 60 % VO_2max) augmented osmotic vasopressin secretion. Blood pressure and heart rate increased with the increase in exercise intensity, and esophageal temperature, plasma lactate concentration, and plasma ACTH concentration increased above 60 % VO_2max. These responses did not occur during hyper tonic saline infusion. The results suggest that the attenuated osmotic vaspressin secretion at the lower exercise intensity might be due to the increased blood pressure, and that the augmented osmotic vasopressin secretion at the higher exercise intensity might be due to the increased body core temperature and/or stress-induced CRH secretion, CRH has been reported to stimulate vasopressin secretion in dogs. In addition, our results demonstrated that osmotic vasopressin secretion did not stimulate ACTH secretion from the anterior pituitary gland. Less

为了阐明热刺激、应激刺激以及渗透压调节对全身加压素分泌的相互作用，我们研究了内毒素血症对大鼠加压素释放的影响及其机制。我们还研究了人类运动期间加压素释放的机制。静脉注射脂多糖（IPS）诱导的内毒素血症，诱导大鼠加压素释放和水摄入行为，而血浆渗透压或血浆容量没有任何变化。脑室内（i.c.v.）给予氯沙坦（血管紧张素 II AT1 受体拮抗剂）几乎完全抑制这些反应，表明大脑血管紧张素 II 通过 AT1 受体参与 LPS 诱导的全身加压素分泌和口渴。为了揭示人类运动过程中加压素释放的机制，我们比较了血浆加压素浓度与口渴之间的关系。 分级周期 ergo 计运动方案期间的血浆渗透压以及静息时高渗盐水输注期间的这种关系。较低强度的运动（< 60% 最大摄氧量 (VO_2max)）会减弱渗透性加压素的分泌，而较高强度的运动（> 60% VO_2max）会增加渗透性加压素的分泌。血压、心率随运动强度增加而升高，食道温度、血浆乳酸浓度、血浆ACTH浓度升高至60%VO_2max以上。这些反应在高渗盐水输注期间并未发生。结果表明，较低运动强度时渗透性加压素分泌减弱可能是由于血压升高，而较高运动强度时渗透性加压素分泌增加可能是由于身体核心温度升高和/或压力诱导的CRH分泌，据报道CRH可以刺激狗的加压素分泌。此外，我们的结果表明，渗透性加压素分泌不会刺激垂体前叶分泌 ACTH。较少的

项目成果

Takamata A, Nose H, Kinoshita T, Hirose M, Itoh T, Morimoto T.: "Effect of acute hypoxia on vasopressin release and intravascular fluid during dyanamic exercise in humans"Am J Physiol Regul Integr Comp Physiol. 279. R161-R168 (2000)

Takamata A、Nose H、Kinoshita T、Hirose M、Itoh T、Morimoto T.：“人体动态运动期间急性缺氧对加压素释放和血管内液体的影响”Am J Physiol Regul Integr Comp Physiol。

Kasai T, Hirose M, Matsukawa T, Takamata A, Kimura M, Tanaka Y.: "Preoperative blood pressure and intraoperative hypothermia during lower abdominal surgery"Acta Anaesthesiol Scand. 45. 1028-1031 (2001)

Kasai T、Hirose M、Matsukawa T、Takamata A、Kimura M、Tanaka Y.：“下腹部手术期间的术前血压和术中低温”Acta Anaesthesiol Scand。

Ito T, Takamata A, Yaegashi K, Itoh T, Yoshida T, Kawabata T, Kimura M, Morimoto T.: "Role of blood volume in the age-associated decline in peak oxygen uptake in humans"Jpn J Physiol. 51. 607-612 (2001)

Ito T、Takamata A、Yaegashi K、Itoh T、Yoshida T、Kawabata T、Kimura M、Morimoto T.：“血容量在人类峰值摄氧量与年龄相关的下降中的作用”Jpn J Physiol。

Takamata A, Seo Y, Ogino T, Tanaka K, Fujiki N, Morita M, Murakami M.: "Effects of pCO_2 on the CSF turnover rate in T1-weighted magnetic resonance imaging"Jpn J Physiol. 51. 555-562 (2001)

Takamata A、Seo Y、Ogino T、Tanaka K、Fujiki N、Morita M、Murakami M.：“pCO_2 对 T1 加权磁共振成像中 CSF 周转率的影响”Jpn J Physiol。

Takamata A, Seo Y, Ogino T, Tanaka K, Fujiki N, Morita H, Murakami M.: "Effects of pCO_2 on the CSF turnover rate in T_1-weighted magnetic resonance imaging"Japanese Journal of Physiology. 51(5). 555-562 (2001)

Takamata A、Seo Y、Ogino T、Tanaka K、Fujiki N、Morita H、Murakami M.：“pCO_2 对 T_1 加权磁共振成像中脑脊液周转率的影响”日本生理学杂志。