Effect of DHEA(S) on the progression of life style related disease : epidemiological and basic analysis.

我们研究了DHEA(S)对生活方式相关疾病进展的影响。脱氢表雄酮与胰岛素抵抗：脱氢表雄酮激活大鼠脂肪细胞p13激酶和非典型PKC。由于这些激活诱导葡萄糖摄取，脱氢表雄酮可能改善胰岛素靶器官的胰岛素抵抗。脱氢表雄酮与肥胖：脱氢表雄酮通过抑制脂肪细胞脂质结合蛋白和固醇调节元件结合蛋白mRNA水平降低PPAR表达水平和甘油三酯体积。脱氢表雄酮可能在脂肪细胞功能中起重要作用。脱氢表雄酮（DHEA）与乳腺癌：脱氢表雄酮（DHEA）作为一种丝裂原，能促进人乳腺癌细胞的增殖，而4-羟基雄烯二酮抑制芳香酶则能减弱这种增殖。服用脱氢表雄酮可能对预防一些与生活方式有关的疾病，如肥胖和糖尿病有好处。

We investigated effects of DHEA(S) on the progression of life style-related diseases.DHEA and insulin resistance : DHEA activated P13-kinase and atypical PKC in rat adipocytes. Since these activation induced glucose uptake, DHEA may improve insurin resistance in the insulin target organs.DHEA and obesity : DHEA decreased the expression levels of PPAR and triglyceride volume through the suppression of mRNA levels in adipocyte lipid-binding protein and sterol regulatory element-binding protein. DHEA might have an important roles in function of adipocytes.DHEA and breast cancer : DHEA increased the human breast cancer cell proliferation as a mitogen, which was diminished with 4-hydroxyandrostendione inhibiting aromatase enzyme.DHEA administration might have an advantage to prevent some of life style-related diseases like obesity and diabetes mellitus.