Effect of inhalational anesthetics for HIF-α mRNA expression in the Septic shock

我们研究了异丙酚（2，6-diisopropylphenol，2，6-diisopropylphenol）对大鼠新皮层c-fos mRNA表达的抑制作用。正常大鼠新皮层c-fos mRNA的表达在暗期前开始增加，暗期后仍保持高水平。提示异丙酚的麻醉作用是通过激活丘脑中线核团发挥的。同时观察了异丙酚20 mg/kg和30 mg/kg剂量组大鼠橄榄核、延髓和大脑皮质c-fos mRNA的表达。10 mg/kg剂量异丙酚对这些核团和皮层的c-fos mRNA无诱导作用，提示较高剂量异丙酚对这些核团有一定影响。

We investigate intravenous anesthetic Propofol (2,6-di-isopropylp h enol) suppress the induction of c-fos mRNA in the rat neocortex which expression begin to increase 2 hours before the dark period and remained elevated following the dark period in a normal rat.Simultaneously, administration of Propofol induce the expression of c-fos mRNA in the midline thalamic nuclei which is also activated by some benzodiazepine narcotic drugs. These indicate that narcotic action of Propofol exhibit via activation of midline thalamic nuclei. We also investigate that c-fos mRNA expression in the olivary nucleus in the medulla and in cereberal cortex in administration of Propofol in the rate of 20mg/kg and 30mg/kg. Rate of 10mg/kg do not induce the c-fos mRNA in these nucleus and cortex suggest that comparative high dose administration of propofol have some affects for these nucleus.