Mechanism of stress-induced derangement of gonadal function in the neuro-endocrine-immune networks

越来越多的证据表明，神经内分泌系统和免疫系统在功能上相互作用。这些相互作用也与应激系统直接相关，应激系统的紊乱会导致神经系统对应激的保护功能受损。在猴海马中，我们发现小胶质细胞在缺血和再灌注开始后表达ELR+ CXC趋化因子及其受体CXCR2，缺血后第4天，猴海马CA1辐射层和分子层的ERβ免疫反应性显著增加。此外，我们发现Unkei-to对CRF反应具有功能性拮抗作用，并可能减轻应激反应，我们评估了草药Unkei-to作为HRT的有效辅助治疗是否对HRT抵抗性绝经期抑郁症状有影响。我们发现Unkei-to治疗在降低抑郁评分方面显着有效，并且Unkei-to是抗hrt绝经期抑郁症妇女的另一种辅助草药治疗选择。

There is a growing body of evidence that the neuroendocrine and immune systems are engaged in a functionally relevant crosstalk with each other. These interactions are also directly linked to the stress system and derangement of this system will lead to the impairment of protective function in neural system against to the stress.In the monkey hippocampus, we found microglial cells expressed ELR+ CXC chemokines and their receptor CXCR2 after the start of ischemia and reperfusion and on day 4 after ischemia, ERβ immunoreactivity increased remarkably in the radiate and molecular layers of CA1 in the monkey hippocampus. Further, we found that Unkei-to has a functional antagonistic action on the response to CRF and may attenuate stress responses, we assess whether the herbal medicine Unkei-to has an impact on HRT-resistant menopausal depressive symptoms as an effective adjunctive therapy combined with HRT. We found treatment with Unkei-to was significantly effective in reduction of depression score and that Unkei-to is another option as an adjunctive herbal therapy in HRT-resistant menopausal depressive women.