Dental Application and Setting Mechanism of Calcium Phosphate Cement Made with Poly (malic acid)

本研究的目的是研究聚苹果酸制备的磷酸钙骨水泥在牙科中的应用。以水泥粉为驱油剂，以P/D=1.0/1.0或1.5/1.0四种不同浓度(10、20、30、40wt%)的热缩聚聚苹果酸水溶液作为水泥浆。测定了水泥的凝结时间、抗压强度和溶解/崩解性能。抗压强度测试后，将试件研磨并进行粉末X射线衍射仪测试。对盘状样品进行了溶解和崩解试验，并用扫描电子显微镜对其进行了观察。采用30%和40%的聚苹果酸作为水泥液，可制得操作性能良好的磷酸钙骨水泥。随着水泥液中聚苹果酸浓度的增加，水泥浆在37℃时的凝结时间显著缩短(p&lt；0.05)。…浓度的增加在水泥液中加入较多的S聚苹果酸可显著提高水泥的抗压强度(p&lt；：0.05)。与苹果酸相比，聚苹果酸制备的水泥具有更大的溶解度和崩解量(p&lt；0.05)。在任何一组水泥样品中都没有观察到羟基磷灰石和其他反应产物的明显峰。目前的研究表明，可以将聚苹果酸和α-TCP粉混合在一起制成聚苹果酸。由聚苹果酸制备的磷酸钙骨水泥的凝结机理为：当α-TCP粉与羧酸水溶液混合时，α-TCPs分解，由于溶液的高酸度而释放出钙离子。释放的钙离子通过螯合反应结合到羧基上。这可能是固化过程中的主要反应。本研究中的实验性磷酸钙骨水泥目前还不能用于临床。这种磷酸钙骨水泥还需要进一步的材料表征和探索。较少

The objective of this research was to investigate dental application for calcium phosphate cement made with poly (malic acid). The cement powder was used for ex-TCP and aqueous solutions of poly (malic acid) obtained by thermal polycondensation in four different concentrations (10, 20, 30, and 40 wt%) were used as the cement liquid at a mixing ratio of P/D= 1.0/1.0 or 1.5/1.0. The setting time, compressive strengths, and solubility/disintegration of the cements were determined. After compressive strength testing, the specimens were ground and subjected to powder x-ray diffractometry. The disc-shaped specimens were examined using SEM after the solubility and disintegration testing. Calcium phosphate cement with workable handling characteristics could be made when 30 and 40% poly (malic acid) were used as the cement liquid. An increase in the concentrations of poly (malic acid) in the cement liquid significantly shortened the setting time at 37℃ (p<0.05). An increase in the concentration … More s of poly (malic acid) in the cement liquid significantly increased the compressive strength (p<:0.05). The cement made with poly (malic acid) showed significantly greater amount of solubility and disintegration compared to malic acid (p<0.05). No noticeable peaks for hydroxyapatite and other reaction products were observed in any of the set cement specimens. The current study showed that could be made by mixing poly (malic acid) and α-TCP powder. The setting mechanism of a calcium phosphate cement made with poly (malic acid) is hypothesized as follows : when α-TCP powder is mixed with an aqueous solution of carboxylic acid, α-TCP decomposes, and Ca ions are released due to the high acidity of the solution. The released Ca ions are bound to the carboxyl groups by a chelate reaction. This may be the dominant reaction during the setting process. The experimental calcium phosphate cements in the present study cannot be used in clinical practice at this moment. Further materials characterization and exploration of this calcium phosphate cement is necessary. Less