Interaction of mineral intake and vitamin D receptor polymorphism on bone mineral density of women

本研究的目的是阐明环境因素、遗传因素及其相互作用与年轻女性骨密度（BMD）之间的关系。采用限制性片段长度多态性（RFLP）方法分析维生素D受体阿帕1和Taq 1基因多态性。采用双能X线骨密度仪测量腰椎和髋关节的骨密度。生活方式通过访谈进行评估。1)BMD与体重、握力和血清全段甲状旁腺激素浓度呈横断面相关。2)BMD是通过婴儿期和青春期前的体重增加来预测的。3)具有“AA”基因型的受试者股骨颈BMD的下降幅度大于具有“Aa”或“aa”基因型的受试者。然而，没有发现环境因素与维生素D多态性之间的相互作用。

The purpose of this study was to clarify associations between environmental factors, genetic factors, and their possible interaction v s.bone mineral density (BMD) of young women. Apa 1 and Taq 1 polymorphisms of vitamin D receptor were analyzed by restriction fragment length polymorphism (RFLP) method. Bone mineral density at the lumbar spine and hip was measured by dual-energy X-ray absorptiometry. Lifestyles were assessed by interview. 1)BMD was cross-sectionally associated with body weight, grip strength, and serum intact parathyroid hormone concentrations. 2)BMD was predicted by weight gain in infancy and the prepubertal period. 3)Subjects with an "AA" genotype had greater decrease in BMD at the femoral neck than those with an "Aa" or "aa" genotype. However, no interactions between environmental factors v.s.vitamin D polymorphisms on BMD were found.