Synthesis of chiral strainer using polydienes containing dialkylamide function

以二硫代苯甲酸苄酯为链转移剂，通过连续阴离子活性聚合和RAFT聚合，合成了聚苯乙烯与聚(L-N-(2-亚甲基-3-丁烯基)-3-甲氧甲基吡咯烷)、聚(St-嵌段-LMPy)的两嵌段共聚物。嵌段共聚物中聚(LMPy)链段的微观结构取决于聚合机理。RAFT聚合得到的聚合物以1，4-结构为主，而阴离子聚合得到了1，4-E，1，4-Z和1，2-的复杂混合结构，将得到的嵌段共聚物溶液与细玻璃微珠混合在微珠表面。然后将聚合物包覆玻璃微珠充填到柱中，用高效液相色谱仪评价其手性识别能力。将外消旋的Pro-混合物带入色谱柱，比较了L-和D-异构体的保留时间。尽管样品浓度和分解温度不同，但不可能有显著的光学分辨率。

Diblock copolymers composed of polystyrene and poly(L-N-(2-methylene-3-butenoyl) -3-methoxymethylpyrrolidine), Poly(St-block-LMPy) were prepared by sequential anionic living polymerization and/or RAFT polymerization using benzyl dithiobenzoate as a chain-transfer agent. The microstructure of poly(LMPy) segment in the block copolymer depends on the polymerization mechanism. 1, 4-structure predominates in the polymer obtained by RAFT polymerization whereas complex mixed structure of 1, 4-E, 1, 4-Z, and 1, 2- were obtained in the polymer by anionic polymerization.THE solution of the block copolymer thus obtained was mixed with fine glass beads to coat the surface of the beads. Then the ability of chiral recognition was evaluated by liquid chromatography by charging the polymer coated glass beads in the column. The racemic mixture of prolin was charged in the column and the retention time for L- and D- isomers were compared. Although variety of sample concentration and resolution temperature, no significant optical resolution was possible.