The analysis of TLR and TCR Vβ repertoire which would determinate and innate immunity

白细胞中的巨噬细胞、树突状细胞、中性粒细胞、NK细胞和γδT细胞对细菌、病毒和异常细胞具有先天免疫。它们具有对抗每种抗原的受体，称为toll样受体（TLR）。在人体系统中，TLR1~9的表达是不相等的，这导致了TLR与配体相遇时细胞释放细胞因子的差异。这些TLR表达的差异将决定感染或肿瘤患者的临床进展。在细胞因子释放的同时，TLR的信号转导会激活MyD88和NF-kB基因，诱导细胞表面表达活化NK细胞或γδT细胞的分子。在相同的患者中也进行了TCR Vβ库的分析。每种TCR Vβ在种群中存在差异。然而，在本研究中未发现TLR表达与TCR Vβ库之间的任何相关性。特别提示，TCR Vβ库可能在诱导所需免疫中发挥重要作用。从现在开始，TLR表达和TCR Vβ库的分析将需要在癌症或感染患者中评估其免疫功能，以制定新的癌症和感染策略。

An innate immunity against bacteria, virus and abnormal cells is carried on the macrophage, dendritic cell, neutrophil, NK cell and γδT cell which belong to white blood cell. They have the receptor against each antigen named toll-like receptor (TLR). In human system, the expressions of TLR1~9 are not equal and that make the differences of cytokine release from the cells when their TLR meet the ligand. These differences of TLR expression would decide the clinical progress in the patients with infection or cancer. As well as the cytokine release, the signal transduction from TLR would activate MyD88 and NF-kB gene, and induce the expression of cell surface molecules which could activate the NK cells or γδT cells.The analysis of TCR Vβ repertoire was also done in the same patients. There were differences in the populations of each TCR Vβ. However, any correlation between TLR expression and TCR Vβ repertoire were not seen in this study. Especially, it was suggested that TCR Vβ repertoire would make an important role to induce a required immunity.From now on, the analysis of TLR expression and TCR Vβ repertoire in the patients of cancer or infection will be needed to assess their immunological function to develop a new strategy for cancer and infection.