Changes in long-term adhesive property and biocompatibility of 4- META/MMA-TBB resin in vitro and vivo.

4-Meta/MMA-TBB树脂已被用于纵折根的粘接和根尖切除术。4- META/MMA-TBB树脂具有良好的生物相容性和生物力学性能，对牙本质和牙骨质具有良好的粘附性能，但有研究表明，未被树脂包裹的胶原纤维在长期使用后可能会受到水降解的影响。目的：评价4- META/MMA-TBB树脂的生物相容性和力学性能在体内外的纵向变化。混合树脂后，分别在马血清或空气中于37 ℃保存1天、1个月、3个月、6个月和1年。1）微拉伸粘结强度（MTBS）：牙骨质在1年和1天的值之间没有差异; 2）硬度：1年高于1天。3）生物相容性：在1年内增加，血清中增加的时间比空气中延迟的时间更长。 ...更多信息 活体生物相容性研究选用2只犬的下颌切牙和前磨牙。牙菌斑污染根管，诱发根尖周炎。他们被分为4组。切除牙根后，将根端表面制备成微凹状，应用超级粘结剂（SB）。EBA组和MTA组制备根管洞并进行根管充填。非充填组不行逆行充填，术后3个月复查X线片和组织学检查。SB和MTA组：牙周膜间隙正常，部分牙根放射线可透区面积较术前减少。几乎没有观察到炎症。结论：4-Meta/MMA-TBB树脂封闭粘接根端，具有良好的生物相容性和力学性能，可获得良好的根尖封闭效果。少

4-META/MMA-TBB resin has been used for the bonding of vertically fractured roots and apicoectomy. It has good characteristics, such as adhesive properties to dentin and cementum.However, some studies demonstrated that the collagen fibrils that are not enveloped by resin may become susceptible to water degradation in the long-term.The purpose: to evaluate the longitudinal changes in biocompatibility and mechanical properties of 4- META/MMA-TBB resin in vitro and vivo.1.Mechanical properties and Biocompatibility: After mixing the resin, these specimens each were stored in horse serum or in air for lday, lmonth, 3month,6month and lyear at 37_. After each periods, they were examined.1)micro-tensile bond strength (MTBS): for cementum, there is not difference between the values at 1- year and at 1-day2)hardness: at lyear was higher than at 1 day. The value in air was higher than in serum.3)biocompatibility: increased within 1 year and this increase was more delayed in serum than in air.2.Cha … More nges of Biocompatibility in vivoMandibular incisors and premolars of 2 dogs were used. The root canals were contaminated with dental plaque and apical periodontitis was induced. They were divided into 4 groups. Following the roots were resected, root-end surface was prepared slightly concave, Super bond(SB) was applied. In EBA and MTA group, root-end cavities were prepared and retrofilled. In no filling group, no retrograde filling was performed.Healing was evaluated radiographically and examined histologically 3months after the surgery. SB and MTA group : a normal periodontal ligament space, and some roots showed reduced area of periradicular radiolucency compared with that before surgery. Little inflammation was observed. In no filling and EBA group, some roots showed enlarged area of periradicular radiolucency compared with that before surgery, and more inflammation was observed.Conclusion: root-end sealing and bonding treatment using 4-META/MMA-TBB resin induce good prognoses by good biocompatibility and mechanical properties. Less