A research on the quantitative analysis of brain lesions caused by hypertension and diabetes mellitus with MRI.

1.我们报告了慢性疲劳综合征患者与年龄匹配的正常对照相比灰质和白质变化的定量分析结果（见参考书目）。在此基础上，分析了高血压和糖尿病患者的变化。然而，由于这些患者存在缺血性脑改变，该分析方法并不直接适用。因此，我们现在正在分析脑血管狭窄或闭塞患者的脑图像，这些患者有轻微的缺血性改变，并准备发表一篇手稿。脑代谢物的变化我们首先用磁共振光谱研究了脑代谢物测量的可重复性。我们发现肌醇的重现性与信噪比呈线性关系。这一结果在加拿大多伦多举行的美国神经放射学会年会上发表。这是一个新颖的结果，已经写了一篇论文，正在提交。脑灌注变化在脑灌注分析中，方法本身就很重要。我们使用分析软件Dr.View 2.0/Linux （AsahiKasei Jyoho System, Inc.）对脑灌注进行了研究。该软件在2006年初进行了修订，并启用了全自动分析，从而实现了更客观的分析。使用这个新引入的系统，我们正在重新分析测试-重新测试脑灌注数据，并准备提交论文。我们还对MRI与pet脑灌注测量的准确性进行了比较研究。

1.Brain anatomical changesWe reported a result of quantitative analysis of gray and white matter changes found in patients of chronic fatigue syndrome compared with age-matched normal controls (see Bibliography). Based on this method, the analysis of the changes in patients of hypertension and diabetes mellitus were analyzed. Owing to ischemic brain changes in these patients, however, the analysis method is not directly applicable. Hence, we are now analyzing brain images of patients with cerebrovascular stenosis or occlusion, who have mild ischemic changes and are preparing a manuscript for publication.2.Brain metabolitic changesWe firstly investigated the reproducibility of metabolite measurements of the brain with MR spectroscopy. We found a linear relationship in myoinositol between reproducibility and signal-to-noise ratio. This result was reported at the American Society of Neuroradiology 43^<rd> Annual Meeting at Toronto, Canada. This is a novel result and a paper was written and is under submission.3.Brain perfusion changesIn the analysis of brain perfusion, the method itself is of large importance. We had been researched on the brain perfusion with the analysis software, Dr.View 2.0/Linux (AsahiKasei Jyoho System, Inc.). This software was revised at early 2006 and enabled fully automatic analysis, that enables more objective analysis. With this newly introduced system, we are reanalyzing test-retest brain perfusion data and preparing a paper for submission. We are also making a comparative study of the brain perfusion measurement with MRI vs.PET for the evaluation of the accuracy.