Ein Ernährungsmuster zur Flavonolaufnahme als Risikofaktor für Pankreaskrebs in der Multiethnic Cohort Study und der EPIC-Studie

在我之前的工作中，我已经报道了黄酮醇（植物性食物中普遍存在的一组多酚）与胰腺癌风险之间的负相关性。黄酮醇潜在的胰腺癌预防作用是一个重要的新发现，现在（a）必须转移到食品层面，以减轻公共卫生建议，（B）有待独立研究证实。拟议的研究项目旨在以独特的国际方法做到这两点。首先，应该在美国的前瞻性多种族队列研究（MEC）中确定与黄酮醇相关的食物模式，在该研究中，我最初观察到黄酮醇与胰腺癌的负相关性。为了推导出食物模式，将应用我们的小组最近在波茨坦引入的降秩回归（RRR）方法，该方法是推导营养流行病学中假设驱动的饮食模式的一种有前途的工具。为了证实这些发现，食物模式随后应该应用于欧洲EPIC（欧洲癌症和营养前瞻性调查）研究，我最近正在进行胰腺癌研究。这种方法的突出特点是结合了两项大型前瞻性研究。由于食物成分表中缺乏黄酮醇，EPIC研究本身无法在这一点上研究这种关联。这项申请涉及在教育部内开展的工作。

In my previous work I have reported an inverse association between flavonols, which are a group of polyphenols ubiquitous in plant foods, and the risk of pancreatic cancer. The potential pancreatic cancer preventive effect of flavonols is an important and new finding, which now (a) has to be transferred to the level of foods to ease public health recommendations, and (b) to be confirmed in independent studies.The proposed research project aims at doing both with a unique international approach. First, a food pattern associated with flavonols should be determined in the prospective Multiethnic Cohort Study (MEC) in the USA, in which I originally observed the inverse association of flavonols and pancreatic cancer. To derive the food pattern the reduced rank regression (RRR) approach will be applied which has recently been introduced by our group in Potsdam as a promising tool to derive hypothesis driven dietary patterns in nutritional epidemiology. To confirm the findings the food pattern should subsequently be applied to and investigated in the European EPIC (European Prospective Investigation into Cancer and Nutrition) – Study, which I am lately conducting pancreatic cancer research in. The outstanding quality of this approach is the combination of two large prospective studies. The EPIC-Study itself would be unable to examine this association at this point due to the lack of flavonols in food composition tables. This application refers to the work to be done in the MEC.