Development of Bioabsorbable Micro-Device for Alveolar Bone Gain

本研究开发了一种可通过热塑性成型为自由形状的纳米复合材料的生物可吸收微器件。生物可吸收微器件如磷酸三钙/聚乙交酯/聚乙交酯/聚(L-丙交酯-乙交酯-co-β-己内酯)通过热混炼得到复合ε-磷酸三钙和聚己内酯。并通过体外和活体实验研究了该装置的力学性能和牙槽骨获得的机制。因此，微型装置具有骨再生所需的机械强度和生物可吸收性。将网状微钉植入大鼠颅骨后，可有效的成骨。在边缘骨缺损和开窗时，将微装置植入犬下颌骨，12周后证实有骨形成。此外，将复合磷酸三钙的微型装置移植到20 mm长的胫骨缺损处，证实了植入后12周可以行走的骨形成，提示所研制的生物可吸收微型装置有助于骨的生长和再生。

In this research, bioabsorbable micro device of the nano composite which can be molded to free form by thermoplasticity was developed. Bioabsorbable micro device as TCP/PLGC have composite β-Tricalcium Phosphate and Poly- (L-lactide-co-glycolide-co-ε-caprolactone) by heat-mixing. And the mechanical property of a device and mechanism of alveolar bone gain were studied by in vitro and in vivo.Consequently, micro device had mechanical strength and bioabsorbable required for bone regeneration. The TCP/PLGC rivet fitted the bone and certainly fixed the micro device.When micro device of mesh form was implanted to Rats calvaria, it was form effective in bone formation. In marginal bone defects and fenestration, when micro device was implanted to canine mandibular, bone formation was confirmed 12 weeks after the implantation. Moreover, when the micro device which combined TCP was transplanted to bone defects of 20mm in length of tibia, the bone formation which can be walked 12 weeks after the implantation was confirmed.It was suggested that developed bioabsorbable micro device contributes to bone gain and regeneration treatment.