Transcriptional mechanism of DNA and TOP 1 and Irinotecan-sensitive examination.

DNA 和 TOP 1 的转录机制以及伊立替康敏感检查。

• 批准号: 19591552
• 负责人: KOYAMA Yoshihisa
• 金额: $ 2.91万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591552/
• 关键词: Top1; イリノテカン; 癌; マイクロドーズ; 担癌; 感受性; クロノセラピー; サーカディアン

There was the confirmation of the medication effect by the circadian rhythm analysis of topoisomerase 1 (TOP1) and examined the anticancer drug effect with the chrono therapy.It is thereby a study to aim at the realization of the personalized medicine by we individualize the drug choice without the burden, and giving medication to the patients.In the first year, we tested it using a cancer cell about circadian rhythm in TOP1.As a result, we put it in TOP1 and were able to confirm a change of the circadian rhythm.We conducted the examination that was available for the medication that used circadian rhythm of TOP1 by anticancer drug administration in the second year.In the last year, we performed the examination by the tumor bearing animal in a living body we put circadian rhythm for the medication that we made use of, and we were useful, or to test it.

通过对TOP1昼夜节律的分析，证实了TOP1的用药效果，并用计时疗法检验了抗癌药物的疗效。因此，通过对TOP1昼夜节律的癌细胞进行检测，第一年，我们用TOP1昼夜节律的癌细胞进行了检测，第二年，我们进行了抗癌药物给药的检查，目的是为了实现个体化用药，无负担地给药。第一年，我们用TOP1昼夜节律的癌细胞进行了检测，结果发现TOP1的昼夜节律发生了变化我们在活体内进行了荷瘤动物的检查，我们为我们所使用的药物设定了昼夜节律，我们是有用的，或者说是测试它。