Transcriptional mechanism of DNA and TOP 1 and Irinotecan-sensitive examination.

通过拓扑异构酶1（TOP1）的昼夜节律分析来确认药物效果，并通过时辰疗法来检查抗癌药物效果。因此，本研究的目的是通过无负担地进行个体化药物选择，并给患者用药，从而实现个体化用药。我们用TOP1中的一个癌细胞来测试它的昼夜节律。结果，我们将其置于TOP 1中，并能够确认昼夜节律的变化。我们在第二次抗癌药物给药中进行了可用于使用TOP 1昼夜节律的药物的检查。一年。去年，我们对活体中的荷瘤动物进行了检查，我们为我们使用的药物设定了昼夜节律，我们很有用，或者测试它。

There was the confirmation of the medication effect by the circadian rhythm analysis of topoisomerase 1 (TOP1) and examined the anticancer drug effect with the chrono therapy.It is thereby a study to aim at the realization of the personalized medicine by we individualize the drug choice without the burden, and giving medication to the patients.In the first year, we tested it using a cancer cell about circadian rhythm in TOP1.As a result, we put it in TOP1 and were able to confirm a change of the circadian rhythm.We conducted the examination that was available for the medication that used circadian rhythm of TOP1 by anticancer drug administration in the second year.In the last year, we performed the examination by the tumor bearing animal in a living body we put circadian rhythm for the medication that we made use of, and we were useful, or to test it.